Monday, December 30, 2019

A Brief Description of Schizophrenia - 1135 Words

According to schizophrenia.com schizophrenia is a complex, debilitating mental disorder that 1-2% of the world population experience. It is a disorder of the brain that affects how people think, feel, and perceive. The purpose of this paper is to explore schizophrenia, in particular its signs, symptoms, etiology and pathophysiology, and then examine drug treatment and their mechanism of action. This will be followed by the prognosis for people with schizophrenia. Signs and Symptoms Early signs of schizophrenia include personality changes that involve abnormal emotional responses, mood disturbance, or depression, as well as cognitive changes (Schizophrenia Society of Canada, 2012). Symptoms of schizophrenia can be classified as positive†¦show more content†¦Dopamine Hypothesis The current dopamine hypothesis suggests that schizophrenia is a result of dysregulation of dopaminergic activity – there is an increase in dopamine D2 binding sites and there are prefrontal D1 deficits (Moncrieff, 2009;). This means that there is over activity of dopamine in certain areas of the brain – possibly leading to positive symptoms – and there is also under activity of dopamine in other areas of the brain – possibly leading to negative symptoms. The original dopamine hypothesis claimed that, rather than dysregulation, there was simply too much dopaminergic activity (Moncrieff, 2009). The dopamine hypothesis came from identification of antipsychotics as dopamine D2 receptor blockers (Nord, Farde, 2011; Miyake, Thompson, Skinbjerg, Dargham, 2011). Schizophrenia has been associated with the dysregulation of additional neurotransmitter systems such as serotonin and glutamate (Moncrieff, 2009). Drug Treatments Antipsychotics have long been the primary drug treatment for schizophrenia (Lehne, 2010). Antipsychotics are split into two main groups: 1) first generation antipsychotics (older, conventional); and 2) second generation antipsychotics (newer, atypical). First generation antipsychotics (FGAs), such as haloperidol are dopamine D2 antagonists. The most common side effects include increased prolactin levels and extrapyramidal effects. Second generation antipsychotics (SGAs), such as clozapine, areShow MoreRelatedA Brief Look at Auditory Hallucinations1332 Words   |  5 Pagespsychosis, specifically schizophrenia, but are also featured in a minority of people that do not have a mental illness. Auditory hallucinations have been known to cause distress in patients that have not found ways to cope with the voices in their head. Internal voices may give the individual a negative or a positive association; most individuals with schizophrenia tend to have negative experiences. As defined by Christos Ballos in an article in the New York Times, schizophrenia is a disorder that isRead MoreSchizophreni A Psychological Disorder1028 Words   |  5 PagesHill College December 7, 2016 Assessment Research paper Schizophrenia is a psychological disorder which about one percent of the population (John et al., fid. 2001) Morbidity is caused by the negative and positive symptoms. Research has shown that disability and impairment is caused by cognitive impairment in schizophrenia. It is by a group of disorders which and it s largely unknown. It involves a set of disturbances of perception, thinkingRead MoreSymptoms And Symptoms Of Schizophrenia1343 Words   |  6 Pages What is Schizophrenia? Experts agree that it is a syndrome (signs and symptoms that are thought to co-occur in ways that distinguish it from other syndromes and from normal thoughts and behaviors). Schizophrenia is also defined as a psychotic disorder with, impairments in reality, disturbances of perception and thought experienced as hallucinations, delusions, hearing voices, seeing things that are not there, and paranoia. Its onset usually starts in a person’s late teens to early twentiesRead MoreAtypical Antipsy chotics.A Brief Overview. Dr. Vipin1114 Words   |  5 Pages A BRIEF OVERVIEW Dr. VIPIN KUMAR, MBBS, DTCD, MD (PSYCHIATRY); CONSULTANT PSYCHIATRIST, AURANGABAD, BIHAR The atypical antipsychotics or second generation antipsychotics (SGA) are a group of antipsychotics that were introduced in the clinical practice during the early 1990. All over world these agents are most commonly prescribed for Schizophrenia and other illnesses with psychotic symptoms. This article will focus on brief overview of the atypical antipsychotics as a class and brief descriptionRead MoreThe Origins Of Schizophrenia, And Greek And Latin Texts Essay1522 Words   |  7 PagesIntroduction History. Some of the earliest evidence of schizophrenia were seen in the Bible, and Greek and Latin texts. In the Bible, people were accused of being demonically possessed or holy based on the visions they saw (if visions involved Jesus). In Greek mythology, individuals were said to be punished by the Gods of they had symptoms of schizophrenia. Between years 1450-1830 in Europe, and North and South America, people were accused of being witches; similarly, in France, people were thoughtRead MoreMental Illness: The Main Symptoms of Schizophrenia 1546 Words   |  7 Pagesthe stigma behind mental illness. Mental illness ranges anywhere from extremely mild cases to some of the more severe illness such as schizophrenia (Brown, Kaylene; Bradley, Loretta J. 2002). Schizophrenia is a mental illness, which affects one percent of the American population. It is a severe mental illness that affects the brain. For many people schizophrenia is debilitating it is known to prevent an individual from being able to have a normal life (Koch, J. 2010). Hearing voices and havingRead MoreGenetic Risk And Outcome Of Psychosis1636 Words   |  7 Pagesthe first paragraph of the introduction and restated again more specifically in the last paragraph. Many researches have been conducted to understand the etiology of schizophrenia, such as genetic factors or environmental factors thus, I believe the problem is researchable. A brief background of the definition the term schizophrenia is defined in the introduction and much information about the topic is explained throughout the introduction. I believe the article indicates all the variables that wereRead MoreMovie Review: Out of Darkness1576 Words   |  7 Pagescondition of Schizophrenia in the movie, Out of Darkness. The film has a dynamic cast including: Diana Ross as Paulie Cooper (the individual suffering with schizophrenia), Rhonda Stubbins-White as Zoe Price (Paulie’s sister), and Beach Richards as Ms. Cooper (Paulie’s mother). There are a number of other characters portrayed in the film; however for the purpose of this paper, the focus is on these three. The first portion of the paper gives a brief description of the initial onset of Schizophrenia for Paulie;Read MoreSchizophrenia - Informative Speech1514 Words   |  7 PagesSchizophrenia Specific Purpose: To inform my audience about schizophrenia and its consequences. Central Idea: Schizophrenia is a serious mental disorder that affects millions of people and it should not be underestimated or ignored. Introduction I. Does anyone have a friend who hears voices that nobody else hears, sees things that nobody else sees or believes that people are controlling his mind and trying to plot against him? A. Well, I do. B. I have a closeRead MoreEssay about Genetics and Schizophrenia1632 Words   |  7 Pagesdiscuss whether schizophrenia is genetically inherited disorder. There will be an understanding to what schizophrenia is with a brief description in the introduction. This essay will also talk about weather schizophrenia is genetically inherited or weather it is a biological (Inherited) disorder. It will also include weather schizophrenia is cause by other factors such as social factors, environmental, pre natal, childhood and neurobiology. The essay will also state weather schizophrenia is caused by

Saturday, December 28, 2019

iOS Development in C# with Xamarin and Visual Studio

In the past, you may have considered Objective-C and iPhone development but the combination of a new architecture and a new programming language together may have been too much. Now with Xamarin Studio, and programming it in C#, you may find the architecture not that bad. You may end up coming back to Objective-C though Xamarin makes feasible any type of iOs programming including games. This is the first of a set of tutorials on programming iOS Apps (ie both iPhone and iPad) and eventually Android Apps in C# using Xamarin Studio. So what is Xamarin Studio? Previously known as MonoTouch Ios and MonoDroid (for Android), the Mac software is Xamarin Studio. This is an IDE that runs on Mac OS X and its pretty good. If youve used MonoDevelop, then youll be on familiar ground. Its not quite as good as Visual Studio in my opinion but thats a matter of taste and cost. Xamarin Studio is great for developing iOS Apps in C# and likely Android, though that depends on your experiences creating those. Xamarin Versions Xamarin Studio comes in four versions: Theres the free one that can create Apps for the App store but those are limited to 32Kb in size which is not a lot! The other three cost starting with the Indie version for $299. On that, you develop on the Mac and can produce Apps of any size. Next is the Business version at $999 and thats the one used for these examples. As well as Xamarin Studio on the Mac it integrates with Visual Studio so you can develop iOS/Android apps as if writing .NET C#. The clever trick is that it uses your Mac to build and debug the App using the iPhone/iPad simulator while you step through code in Visual Studio. The big version is the Enterprise edition but that wont be covered here. In all four cases you need to own a Mac and to deploy Apps in the App store needs you to pay Apple $99 each year. You can manage to offset paying that until you need it, just develop against the iPhone simulator that comes with Xcode. You have to install Xcode but its in the Mac Store and its free. The Business edition does not have a big difference, just that it is on Windows instead of the Mac with free and Indie editions, and it uses the full power of Visual Studio (and Resharper). Part of that comes down to whether you prefer to develop Nibbed or Nibless? Nibbed or Nibless Xamarin integrates into Visual Studio as a plugin that gives new menu options. But it doesnt yet come with a designer like the Xcodes Interface Builder. If you are creating all your views ( the iOS word for controls) at runtime then you can run nibless. A nib (extension .xib) is an XML file that defines the controls etc in views and links events together so when you click on a control, it invokes a method. Xamarin Studio also requires you to use Interface Builder to create nibs but at the time of writing, they have a Visual designer running on the Mac in alpha state. It will likely become available on the PC as well. Xamarin Covers the Whole iOS API The whole iOS API is pretty massive. Apple currently has 1705 documents in the iOS developer library covering all aspects of iOS development. Since they were last reviewed, the quality has improved a lot. Likewise, the iOS API from Xamarin is pretty comprehensive, though you will find yourself referring back to the Apple docs.​ Getting Started After installing Xamarin software on your Mac, create a new Solution. The project choices include iPad, iPhone, and Universal and also with Storyboards. For iPhone, you then have the choice of an Empty Project, Utility Application, Master-Detail Application, Single View application, Tabbed Application or OpenGl Application. You have similar choices for Mac and Android development. Given the lack of designer on Visual Studio, you can take the nibless (Empty Project) route. Its not that difficult but nowhere as easy to get the design looking spot on. In this case, as you are mainly dealing with square buttons, its not a worry. Architecting iOS Forms You are entering into a world described by Views and ViewControllers and these are most important concepts to understand. A ViewController (of which there are several types) controls how data is displayed and manages view and resource management tasks. The actual displaying is done by a View (well a UIView descendant). The User Interface is defined by ViewControllers working together. Well see that in action in tutorial two with a simple nibless App like this one. In the next tutorial, well look in depths at ViewControllers and develop the first complete App.

Sunday, December 22, 2019

I Attended Wheaton s Christmas Festival - 830 Words

For this extra credit concert review, I attended Wheaton’s Christmas Festival. I was going anyway and thought I would write a review for it to get some kind of credit. There was a lot performed during this concert and it is not possible to discuss everything in detail so I will discuss the overall atmosphere and some of the specific performances that I particularly enjoyed. The concert started with Claire Holly singing Once in a Royal David’s City composed by Henry J. Gauntlett in 1849 (Hawn and Hanna). It was a solo performance and it was peaceful. The Symphonic Band then played and this was followed by everyone, including the audience, singing Come thou Long Expected Jesus composed by Charles Wesley in 1744 (Carrol). Next, which I will discuss in more detail, Wolcum Yole composed by Benjamin Britten in 1942 (Wolcum Yole!). This was interesting to listen to because we have spoken about Benjamin Britten in class. This piece was mainly monophonic and contained a lot of a gitated style. It was not smooth; it was all over the place. This is a much more modern song as one can tell. It strays away from the much more conservative-style pieces that Giovanni Artusi was an advocate for in the sixteenth and seventeenth centuries. Several more songs were played and sung by the Concert Choir, Women’s Chorale and the Percussion Ensemble which were followed by my favorite piece in the concert, Fum Fum Fum which was thought to be composed in the sixteen or seventeenth centuries but was notShow MoreRelated_x000C_Introduction to Statistics and Data Analysis355457 Words   |  1422 PagesMacintosh are registered trademarks of Apple Computer, Inc. Used herein under license. Library of Congress Control Number: 2006933904 Student Edition: ISBN-13: 978-0-495-11873-2 ISBN-10: 0-495-11873-7 ââ€"   To my nephews, Jesse and Luke Smidt, who bet I wouldn’t put their names in this book. R. P. ââ€"   To my wife, Sally, and my daughter, Anna C. O. ââ€"   To Carol, Allie, and Teri. J. D. ââ€"   About the Authors puter Teacher of the Year award in 1988 and received the Siemens Award for Advanced

Friday, December 20, 2019

An Idea That Protects A Proprietor s Land Title - 1742 Words

Indefeasibility Introduction Indefeasibility of title is an idea that protects a proprietor’s land title. It allows for the proprietor to be immune from attack by adverse claims and interests in the land, in which he, the proprietor, is registered. This concept is based around the Torrens system in New Zealand, this concept consists of three main principles, the mirror, the curtain and the insurance principles. This essay will discuss the concept of indefeasibility of title, the Torrens system and how these have provided security of title for land owners in New Zealand. I will also report on two significant cases that will illustrate the concept of Indefeasibility of title, they are Frazer v Walker and Efstratiou, Glantschnig and Petrovic v Glatnschnig. Common Law Common law was implemented in New Zealand when the British settlers arrived. It was in accordance with English law and was known as the Deeds system and Act and was replaced by the Torrens system in 1870. Common Law basically stated that no one could confer a better title than the one they have and therefore if a deed was deemed invalid, so too was the title (Hinde 2013). Torrens System The Torrens system is what indefeasibility of title has been built around. It has existed since 1870 and has been refined and is now found in the Land Transfer Act 1952. The system, as mentioned earlier, consists of three principles, the mirror principle, the curtain principle and the insurance principle. †¢ The Mirror principle:Show MoreRelatedThe Objectives Of The Lra 2002 Replaces And Repeals The Land Registration Act 19251432 Words   |  6 Pagesreplaces and repeals the Land Registration Act 1925 in its entirety. However, the same principle which also applied in 2002 Act. Law based on these three principles. The â€Å"Mirror principle† provide that by the register should reflect or reflect all the rights and interests of the registered land titles. The curtain principle which is purchasers need look no further than the register and are not concerned with trusts. The â€Å"Insurance Principles† is a simple, if the title is officially registeredRead MoreCase Analysis : Business Partnership1433 Words   |  6 PagesWhile many companies are formed by investors, best friends, or family members it is always a good idea to register the company and make it a legal partnership. Partnership agreements serve several purposes, but mostly it will benefit all parties inv olved. In this scenario, assuming Chad wants equal decision making rights but not the liability of the company’s debt LLP is a good option to register the company under, also assuming that Dad wants the same for his son Chad. For instance, â€Å"In a limitedRead More Revolution Essay2438 Words   |  10 Pagesfrom 1764-1766. Britain’s national debt had soared to 133 million pounds due to the war. Grenville decided to propose several taxes on the American colonists, including the Stamp Act. The Stamp Act required embossed markings on court documents, land titles, contracts, playing cards, newspapers, and basically anything printed. Grenville figured that the tax would cover part of the national debt and the cost for keeping ten thousand soldiers in America—roughly 200,000 pounds per year. The ColonistsRead MoreThe Effect of the Wapping Revolution on British Journalism Essay1818 Words   |  8 PagesThe Effect of the Wapping Revolution on British Journalism In 1986, when Rupert Murdoch, the owner of News International, moved production of his major titles (The Times, The Sunday Times, The Sun and The News of the World) from Fleet Street to Wapping, he set about an irreversible chain reaction in the structure of journalism in the UK. Although I believe that some kind of major political and technological change in the press was inevitable and arguably overdue byRead More‘Charles’ Ability to Finance His Government Effectively and Without Too Much Resentment During the Personal Rule Was a Remarkable Achievement.’2100 Words   |  9 Pages‘Charles’ ability to finance his government effectively and without too much resentment during the personal rule was a remarkable achievement.’ How Far Do You Agree? For the greater part of the 1630’s Englishmen paid their taxes, most likely grumbling whilst doing it, but they were paid. During his personal rule 1629-40, Charles I needed to raise revenue by using non-parliamentary means, i.e. in ways he would not need a parliament’s permission to collect. In order to do this, Charles changedRead MoreRace And Ethnicity From An Anglo American War Of 1846 And The United States3084 Words   |  13 PagesIn the span of 50 years a lot can change especially when a power struggle began brewing between land hungry President James Polk of the United States and recently independent Mexico. California began its transition from the dominance of Spanish powered Missions to independent Ranchos. In Two Years Before the Mast Richard Henry Dana Jr explores the issue of race and ethnicity from an Anglo perspective in newly opened for trade to foreigners California. From the PBS website, one is able to learn aboutRead MoreForms of Commercial Organizat ion12473 Words   |  50 PagesA Business Organization which is owned and managed by a single person with or without the help of family members is called as sole trader or sole proprietor. The sole trading concern is run on the principle â€Å"All is he and he is all in all†. 1.1 Features 1. One-man Ownership and Control A sole trading concern is owned by an individual. The proprietor is the sole owner and master of the business. He independently manages and controls the business without the interference of any other person. 2.Read MoreEssay on Edgar Allan Poe2364 Words   |  10 Pages Edgar Allan Poe nbsp;nbsp;nbsp;nbsp;nbsp;Ralph Waldo Emerson called him the jingle man, Mark Twain said that his prose was unreadable, and Henry James felt that a taste for his work was the mark of a second-rate sensibility. According to T. S. Eliot, quot;the forms which his lively curiosity takes are those in which a preadolescent mentality delights.quot; After notices like those, most reputations would be sunk without a trace, and yet Edgar Allan Poe shows no sign whatsoever of looseningRead MoreMedia Law: Defamation, Copyright, Etc23627 Words   |  95 Pagesdocuments such as pleadings and proofs of evidence: This will not protect media reports of the contents of these documents. A fair and accurate report by newspaper, radio or television of proceedings publicly heard before any Court exercising judicial authority shall, if published contemporaneously with such proceedings, be privileged (provided no blasphemous or indecent matter is included) - Section 6 Wrongs Act. This section protects reports of proceedings heard before a Court exercising judicialRead MoreMedia Law: Defamation, Copyright, Etc23639 Words   |  95 Pagesdocuments such as pleadings and proofs of evidence: This will not protect media reports of the contents of these documents. A fair and accurate report by newspaper, radio or television of proceedings publicly heard before any Court exercising judicial authority shall, if published contemporaneously with such proceedings, be privileged (provided no blasphemous or indecent matter is included) - Section 6 Wrongs Act. This section protects reports of proceedings heard before a Court exercising judicial

Saturday, December 14, 2019

Exploring Modernism In Architecture Architecture Essay Free Essays

string(254) " which was developed by Dr Jonas Salk, the developer of infantile paralysis vaccinum had intended for a research lab which was non merely someplace for biological research, but a topographic point which you could ‘invite a adult male like Picasso\." For my essay on Modernism in architecture I intend to research an designer of the modernist period in order to set up the signifier, doctrine and societal thoughts behind modernism. ‘The term modern architecture is equivocal. It can be understood to mention to all edifices of the modern period regardless of their ideological footing, or it can be understood more specifically as an architecture conscious of its ain modernness and nisus for alteration. We will write a custom essay sample on Exploring Modernism In Architecture Architecture Essay or any similar topic only for you Order Now ‘ Modern architecture is a class which normally complements edifices of the twentieth and twenty-first century. It would include Bauhaus / International manners ( sometimes used to depict Bauhaus architecture in United States ) and besides brutalism. Modernism was a reaction against eclectic method and the munificent stylistic surpluss of the Art Deco, Art Nouveau and the Victorian ages. However, it is still a affair of gustatory sensation. Even though Bauhaus, a German design school 3 ( Operated from 1919-33 By laminitis Walter Gropius, so by Hans Mayer and Ludwig Mies der Van Rohe ) which had deeply influenced humanistic disciplines and architecture had been more concerned with societal facets of design ; none the lupus erythematosus, International manner shortly became a symbolism of Capitalism. Fig.2 shows an interesting and most celebrated illustration of this International manner. This manner of architecture was reserved chiefly for office blocks, but was besides seen in places built for the rich and celebrated. Fig.2 shows another edifice widely known for its ‘functionalist aesthetic and a chef-d’oeuvre of corporate modernism. ‘4 5 There were many designers who attached their name to this modernistic epoch, some of the best known being Frank Lloyd Wright ( fig.6 ) , Walter Gropius ( fig.5 ) , Le Corbusier ( fig.2 ) and Ludwig Mies der Van Rohe ( fig.3 ) . 6Fig.6 shows Falling H2O which was a genuinely iconic edifice for many. Willard huntington wrights design which was for a residential place was above a waterfall. This edifice portrayed his position of organic architecture. Modern architecture was found to be disputing traditional instructions which were thought to be suited for architectural design and construction. Modernist ‘s interior decorators went on to reason that designers should plan everything which is necessary for society. From every item and furniture in the inside and outsides of edifices and even led to designers planing the most low of edifices. I have looked at the broader definition of modernism along with the innovators who drove this manner. Louis Kahn is the designer I have chosen to analyze in deepness. His positions of modernism are good known through the modern universe of architecture. Louis Kahn 7 Itze-Leib Schmuilowsky ( February 20, 1901 or 1902 – March 17, 1974 ) , or more normally known in the universe of architecture as Louis Kahn was an designer who was infused within the International manner. Kahn graduated from the University Of Pennsylvania School Of Fine Arts in 1924. In the late 1930 ‘s Kahn ‘s was working as a adviser to the Philadelphia Housing Authority. His association with modern architecture grew as he worked with Europeans Stonorov and George Howe with whom Kahn designed many wartime lodging undertakings which can be seen in fig.8. From these experiences it gave Kahn a sense of societal duty which was subsequently reflected in his doctrine. 1947 was a twelvemonth where the Kahn started to emerge. His calling had established to a point where he had started a learning calling at Yale University as the Chief Critic in Architectural Design and Professor of Architecture, until 1957. Then at the University of Pennsylvania as Cret Professor of Arc hitecture until his decease lonely decease in a work forces ‘s room lavatory in Pennsylvania Station in New York. Kahn died in deep debt despite his flush calling. 8 Louis Kahn was a review of mainstream modernism ; his work represented the New Monumentality motion which was besides promoted by Siegfried Gieldion, Josep Llios Sert and Kahn ‘s wise man George Howe. Kahn ‘s edifices are improbably precise in their building of topographic points for people. I found some pieces of Kahn ‘s work peculiarly interesting to analyze from a modernistic architectural position. From the list of his most of import plants I have selected a few which I believe to be peculiarly symbolic to this essay. From more than a twelve houses which had been designed by Kahn Esherick House was the most celebrated. I found Esherick house to one of his most fantastic pieces of work which shows us the way which he subsequently followed in. A critique say ‘s: 11 9 ‘aˆÂ ¦The Esherick House is decidedly one of Kahn ‘s most of import plants which defined lessons he ‘d travel on to utilize in ulterior undertakings. ‘ 12 10 By this I believe he means that Kahn was happening his component which he had so travel onto usage in ulterior undertakings. Kahn ‘s calling comprises of a batch of interesting work, nevertheless, Esherick house stands as one of his most of import pieces of work. In the devising of the house the control of visible radiation had been the preoccupation since the start, and he genuinely had achieved harmoniousness through natural visible radiation every bit good as distinguishable manner through the transcendency and geometric item. Kahn ‘s rules of visible radiation, materiality and geometry are clearly seeable here. He starts to enforce his future positions of signifier in elusive features of this house. At a glimpse it is merely concrete and wood which combine to make the frontages and interior infinites. The house features a textured howitzer coating, with keyhole window which are framed with natural Apilong wood placed at irregular intervals on the forepart facade. The floor program is a refined design by Kahn. It is shown to incorporate two symmetrical rectangles which allow structural support and openness. This truly modernistic construction shows how Kahn ‘s work would blossom in ulterior old ages. The Esherick house ‘s pure usage of geometry and abstract signifier reflect his modernistic attack to architecture. Kahns work is much greater dipected in his later and much larger undertakings. The Salk Laboratories which was developed by Dr Jonas Salk, the developer of infantile paralysis vaccinum had intended for a research lab which was non merely someplace for biological research, but a topographic point which you could ‘invite a adult male like Picasso. You read "Exploring Modernism In Architecture Architecture Essay" in category "Essay examples" ’13 The stuffs used for this huge undertaking were concrete, wood, marble and he besides used the component of H2O in his design which as the monolithic composite was juxtaposed against the Pacific Ocean was suiting. I found a really fitting description of The Salk research labs: Kahn ‘s usage of order before signifier shows us how he depicted a edifice to be like a perfect being with complexness of usage inside every bit good as on the outside. I found a really interesting quotation mark from Kahn about the Salk laboratories. His doctrine of design shows use the sort of adult male he was and purposes he perused: â€Å" I did non follow the dictates of the scientists, who said that they are so dedicated to what they are making that when lunch period comes all they do is clear off the trial tubing from the benches and eat their tiffin on these benches. I asked them: was it non a strain with all these noises? And they answered: the noises of the iceboxs are awful ; the noises of extractors are awful ; the trickling of the H2O is awful. Everything was awful including the noises of the air-conditioning system. So I would non listen to them as to what should be done. And I realised that there should be a clean air and chromium steel steel country, and a carpet and oak table country. From this realization signifier became. I separated the surveies from the research lab and placed them over gardens. The garden became out-of-door infinites where one can speak. Now one demand non pass all the clip in the research labs. When one knows what to make, there is merely small clip one needs for making it. It is merely when 1 does non cognize what to make that it takes so much clip. And to cognize what to make is the secret of it all. † I deduce from this extract Kahn ‘s cognition and assurance. I see how Kahn believed in a new modern signifier of architecture. He says it as if he already has the ideas and thoughts to transform edifices into styled and ordered infinite. Kahn ‘s readings were apparently much clearer ; he wanted a modern architecture less concerned with aesthetics and what the edifice looks like. He was more intrigued by the infinites of the edifice and how the infinites were being used, and what order this would make for them. He wanted to do infinites which would impact the experiences of those who inhabited those infinites. Salk research lab shows us a design which had preponderantly established the foundational significance ; order of infinite an so the geometries. He used this construction of idea for his designs of all establishments such as Salk laboratories. ‘The concluding version of the Salk research labs brought him to accept a solution in which services were as ‘repressed ‘ or concealed as in any office edifice by Mies Van der Rohe ‘ From this big undertaking he moved onto a following, nevertheless, this one staying unbuilt whilst he was still populating. Jatiyo Sangshad Bhaban in Dhaka, Bangladesh is regarded to be on this is great memorials of international modernism. This edifice was considered as his chef-d’oeuvre of his life-time. Construction of this edifice had stated by 1961 nevertheless due to its huge outrageousness did n’t complete building until nine old ages after his decease in 1983 which means it took around 20 old ages to construct. The national assembly edifice was Kahn ‘s most of import piece of work. The infinite was really expansive. The interior country for the Assembly edifice was spilt into 3 subdivisions. The zone in the Centre provides circulation. The chief country or cardinal zone is for the chief assembly. The exterior zone is where the offices and sofas are, besides this is where the entryway to the chief mosque is. In the design we can see how natural visible radiation is a really of import component in this edifice. The edifice seems as if it is entirely for spiritual intents and has a heavy religious genius. â€Å" In the assembly I have introduced a light-giving component to the inside of the program. If you see a series of columns you can state that the pick of columns is a pick in visible radiation. The columns as solids frame the infinites of light. Now think of it merely in contrary and believe that the columns are hollow and much bigger and that their walls can themselves give visible radiation, so the nothingnesss are suites, and the column is the shaper of visible radiation and can take on complex forms and be the protagonist of infinites and give visible radiation to infinites. I am working to develop the component to such an extent that it becomes a poetic entity which has its ain beauty outside of its topographic point in the composing. In this manner it becomes correspondent to the solid column I mentioned supra as a giver of visible radiation. † Here Kahn negotiations about the Bangladesh undertaking. He reiterates the importance of visible radiation in the infinite and his poetic entity which he adds to every design to make a great sense of beauty. In the designing of these three undertakings we can see how Kahn has used his cognition to assist make infinites which execute both signifier and map desirably to the client. Kahn negotiations about how his greater apprehension of what is needed helps him finish his undertaking easy. Kahn negotiations approximately beauty as the great philosopher St Thomas Aquinas did. Aquinas believed that beauty consisted of four ingredients: Integrity, integrity, symmetricalness, and glow. By unity he meant that something is complete on its ain without any being dependent on anything outside it. By integrity he means every portion has a ground and ca n’t be taken off without destructing the whole beauty of it. Symmetry mentioning to equilibrate, something ca n’t merely alter without a corresponding consequence. This was similar the invariables which had appeared in Kahn ‘s work. The sense of composing, the unity of a edifice fear for stuff, sense of ‘room ‘ , light as the shaper of the construction and architecture of connexion Kahn tried to use these theoretical accounts into all of his undertakings. One even described him as: â€Å" a philosopher among designers † . This is from his every showing doctrine on his work. Basically Kahn saw architecture as being a religious signifier of communicating. He grew a strong relation with each undertaking by using a strong hierarchy with order being the most of import. Kahn was celebrated for being a review of modernism. He found many influential designers of the clip to hold been misjudging the order of their designs. Kahns critue started with him rejecting a ‘free program ‘ ; a construct which Mies new wave der Rohe and Le Corbusier had attached themselves to, along with modernism. Kahn believed that dividing these two constructs of signifier from the construction, would intend the free program as antecedently interpreted by Van de Rohe and Le Corbusier had ‘ opened up a nothingness that could merely be filled with subjective intuition. ‘ Basically Kahn ‘s work did look consistent with that of the broader position of architecture nevertheless, his position of modern architecture was something which was unpredictable and had no regulations to follow or rules to ad ear to. He found that the international manner of modern architecture at the clip which was being used by many designers in America and Europe had been excessively concerned with the signifier and non the map. ‘Kahn was concerned with the things adult male has been looking for since the beginning – and in this he was a fundamentalist – was non interested in the realisation, of something which had already occurred, but in the possibility that something will happen within the wallsaˆÂ ¦ ‘ This tells us that Kahn was more of Prophet than merely a sermonizer. He wanted to alter the positions on architecture and present what he believed to be the necessary status for the presence of architecture. ‘Mies ‘s sensitivites react to imposed structural order with small inspiration, Le Corbusier passes through order impatiently and hastes to organize. ‘ Kahn talked about Mies Van der Rohe and Le Corbusier imperfectness in structural order, and their haste of order leads to an imperfectness in signifier. Kahns order derived from nature and this is reflected in his undertakings. ‘In the nature of infinite is the spirit and the will to be in a certain manner. Design must closely follow that will. ‘ The pure order, signifier and geometry is why Louis Kahn still act upon the universe today. His work straight impacts and inspires signifiers of architecture today such as station modernism and neo positivist. More than this Louis Kahn redefined modernism. He has thrilled looker-ons with his huge doctrine ; nevertheless his frequenters merely appeared in his ulterior old ages. Kahn adapted architecture and had an input as to what we see when we analyse today. He showed us in his huge texts, to every item the visions he had, and how he intended to raise these visions. Predominately we can see that he was floating off from modernism, nevertheless, I have studied how Kahn ‘s vision set modernism into path someplace that it would n’t hold been without his influence. â€Å" It was non belief, non design, non pattern, but the kernel from which an establishment could emerge†¦ † How to cite Exploring Modernism In Architecture Architecture Essay, Essay examples

Thursday, December 12, 2019

Intimate Relationship and Communication Sample Essay Example For Students

Intimate Relationship and Communication Sample Essay Self-concept and Self Esteem* To hold successful relationships. we must first accept and experience good about ourselves. * A positive self-concept and a healthy degree or self-esteem aid us love and esteem others. * As grownups. we likely have a sense that we’re fundamentally loveable. worthwhile people and that we can swear others is. as babes and kids. we felt loved. valued and respected ; if grownups responded to our demands in a moderately appropriate manner ; and if they gave us the freedom to research and develop a sense of being separate persons. * Harmonizing to psychologist Erik Erikson. it continues to develop as we encounter and resolve assorted crises at each phase of life. * Gender function – the activities. abilities. and features our civilization deems appropriate for us based on whether we’re male or female. * Our grownup manners of loving may be based on the manners of fond regard we established in babyhood with our female parent. male parent or other primary health professional. Peoples who are secure in their intimate relationships likely had a secure. swearing. common fulfilling fond regard to their female parent. male parent or other parenting figure. * People’s earliest experiences and relationships were less than ideal. nevertheless. they can still set up fulfilling relationships in maturity. Peoples can be resilient and flexible. They have the capacity to alter their thoughts. beliefs and behaviour forms. They can larn ways to raise their self-esteem ; they can go more trustful. accepting. and appreciative of others. Friendship* Friendships spring people the chance to portion themselves and detect others. * The friendly relationships we form in childhood are of import in our development ; through them we learn about tolerance. sharing and trust. * Companionship – Friends are relaxed and happy in each other’s company. They typically have common values and involvements and do programs to pass clip together. * Respect – Friends have a basic regard for each other’s humanity and individualism. Good friends respect each other’s feelings and sentiments and work to decide their differences without take downing or contemptuous each other. There are besides honorable with each other. * Acceptance – Friends feel free to be themselves and show their feelings without fright of ridicule or unfavorable judgment. * Help – Sharing clip. energy and even material goods is of import to friendship. Friends know they can trust on each other in times of demand. * Trust – Friends are secure in the cognition that they will non deliberately hurt each other. * Loyalty – Friends can number on each other. They stand up for each other in both word and title. * Mutuality – Friends retain their single individualities. but close friendly relationships are characterized by a sense of mutualness – â€Å"what affects you affects me. † Friends portion the ups and downs in each other’s lives. * Reciprocity – Friendships are mutual. There is discussion between friends and the feeling that both portion joys and burdens more or less every bit over clip. * Friendships are normally considered both stabler and longer enduring than intimate partnership. Friends are frequently more accepting and less critical than lovers. likely because their outlooks are different. Love. Sexual activity and Familiarity * Love encompasses antonyms: fondness and choler. exhilaration and ennui. stableness and alteration. bonds and freedom. * Love does non give us perfect felicity. but it does give our lives intending. * Love reflects the positive factors that draw people together and prolong them in relationship. * Sex brings exhilaration and passion to the relationship. * It intensifies the relationship and adds captivation and pleasance. * The finding to go on. reflects the stable factors that help keep the relationship. Sternberg’s Love Triangle Uncle Dan EssayGender and Communication* Men tend to utilize conversation in a competitory manner. possibly trusting to set up laterality in relationships. * Women tend to utilize conversation in a more affiliative manner. possibly trusting to set up friendly relationship. * Men tend to speak more – though without unwraping more – and listen less. Womans tend to utilize good listening accomplishments such as oculus contact. frequent nodding. focussed attending. and inquiring relevant inquiries. Conflict and Conflict Resolution* Clarify the issue – Take duty for believing through your feelings and detecting what’s truly trouble oneselfing you. Agree that one spouse will talk first and have the opportunity to talk to the full while the other listens. Then change by reversal the function. Agree to speak merely about the subject at manus and non acquire distracted by other issues. * Find out what each individual wants – inquire your spouse to show his or her desires. Don’t presume what your spouse wants to talk for him or her. * Identify assorted options for acquiring each individual what he or she wants – pattern brainstorming to bring forth a assortment of options. * Decide how to negociate – work out some understandings or programs for alteration. * Solidify the understandings – travel over the program verbally and compose it down. if necessary ; to guarantee that you both understand and agree to it. * Review and renegociate à ¢â‚¬â€œ make up ones mind on a clip frame for seeking out the new program. and put a clip to discourse how it’s working. Make accommodation as needed.

Thursday, December 5, 2019

Selected Aspect Of The Microbreweries Boom â€Myassignmenthelp.Com

Question: Discuss About The Selected Aspect Of The Microbreweries Boom? Answer: Introducation The machines Easy Brew will make crafting of beer delightful for customers at the comfort of their home with latest technology. Customers can brew beer with products of the company using in-built recipes as well as recipes and natural ingredients for brewing will be delivered at doorstep by Easy Brew community. The machine will be targeted to the university students and young population of New South Wales. The machine is planned to be distributed from Sydney to Wollongong and Newcastle and other parts of New South Wales. The sales of the machines is expected to increase by 15% every year so that revenue of 1.2 million AUD can be obtained by third year of operation. The fine quality of products will delight customers of New South Wales as they can brew beers at home after just one-time investment in purchasing machines of Easy Brew.(Schaper et al 2014). Marketing The Company aims to gain customers for repeat purchase by delivering quality products to customers. The product will focus on excellent taste of beer which will attract loyal customer base. The company will promote itself as a Youth Brand and will aim to position itself as a brand with excitement personality. The company will make use of both Above the Line and Below the Line promotional activities for promoting the product. The products will be promoted in industry show of liquor, fairs and will target campus university students and youths. Online promotional strategy on digital platforms will also be used to gain a good customer base (McKeever 2016). The organization which manufactures Easy Brew will have separate divisions for the, bottling and shipping process, production and delivery process. The manufacturing of products will follow high quality standards and products will be equipped modern technology. The Easy Brew machine will be available to customers online and can be ordered by mobile apps for home delivery in Sydney. The company will deliver Easy Brew machine based on Just-In-time technology for premium products. The company will make payment easy and safe for customers online by building a safe digital platform (Gnauck, Hart and Pagel 2014) Initial investment of 150,000 AUD will be required by Easy Brew to begin its operation. The manufacturing will start with loans from banks, investment from friends and family and will fund itself by angel investors and venture capitalists for expanding its operation in New South Wales. The price of EasyBrew machines will be reduced by 12% for first 6 months so that the Company break evens and becomes profitable. After two years, 20 % bottom-line profitability is expected. The machines of Easy Brew are expected to achieve increase 15 % sales year on year so that revenue at the end of third year can be expected to be 1.2 million AUD. 1.1 MISSION STATEMENT- To delight customers by delivering them high-quality beer machines which will make the brewing process delightful for them at comfort of home. The company which manufactures Easy Brew started its operation in Sydney, New South Wales. Within 2 years of operation the Easy Brew machines have gained popularity among customers of Sydney. Distribution of Easy Brew has been planned for expansion so that the products can be available in all markets of New South Wales. The company has 20 people in sales, delivery and production. The Easy Brew machines make crafting of beer at home easier by modern technology , customers can select their recipes from RFID tags of machine, some machines of EasyBrew are automated and in the premium range to make crafting of beer delightful at comfort of home for customers(Watne and Hakala 2013). The business goals of Easy Brew are as follows- 1)To achieve a growth of sales revenue to 1.2 million AUD by the third year of its operation. 2) To distribute products through online platform like company website, through websites like Direct Shop and mobile apps. 3) To expand its distribution in popular cities of Australia like Sydney, Wollongong and Newcastle within next five years. 4) To deliver products of high quality to customers and to remove any obstacle between the product and customer by delivering them high quality products which can make the brewing process easy and delightful so that customers make repeat purchase. 5) To promote the products on digital platforms by making customers aware about easy brewing at home and by building customer relationships using digital tools like data mining and e-mail marketing and make home delivery available for customers (Leschke 2013). Regional producers have dominated the beer market in New South Wales and Sydney. The company faces indirect competition from ready- made beer brands like Malt Shovel Brewery which is a part of Lion, St Arnou, Stockade Brew Co and Pines Brewing Company. Regional beer companies in Sydney and New South Wales have to compete with brands like Lion, Carlton and United Breweries and Coopers Brewery. It is difficult for Easy Brew products to promote the new concept of brewing beer at home. New South Wales has 7.7 million populations which is almost one third of Australias population. More than 5 million people live in Sydney and Wollongong and Newcastle have three fourth of population of NSW. The state has popular universities like University of Sydney, University of New Castle and University of New South Wales and there are 35% sales of beer in among college campus communities. Population in the state grows because of immigration and industry growth which can add to customer base of Easy Brew(Argent 2017). Product And Target Market The machine Easy Brew will make the craft of brewing easy for customers. The machines will be equipped with computerized program for customers to create recipes of their own. Fresh grains, yeast and hops will be delivered to customers along with machines of Easy brew. Around 6 litres of beer can be manufactured within 2 hours using Easy Brew products. Easy Brew will have fully automated machine called Easy Brew Pro which will be priced in premium range. Thecompany targets two sets of customers in Sydney and New South Wales-customers who study in Universities and young men and women in the age bracket of 25-30 living in the cities by making the product available in popular pubs and local markets(Hollensen 2015). The producers of Easy Brew must obtain license to distribute its products to customers. Standard hours for trading will be applied to the license and the license can be applied as an individual or corporation. Consent of Local Council will be required and if the applicant of license is an individual, Certificate of Responsible Service of Alcohol must be provided. Ogranizational Structure And Staffing The organization structure of manufacturer of Easy Brew product will be flexible with less hierarchy and there will be managers for the manufacturing, shipping operations, digital marketing and sales division. The company will follow a Just-in-time technology for shipping of beer machines. An open communication will be followed throughout the organization and all departments will collaborate with each other for a smooth flow of information. (Russell-Jones 2014). Equipment Required Equipment required for manufacturing the products of Easy Brew will be gallon pot, airlock, stopper, hydrometer jar , nylon bags(Thomas 2013). The production process will follow the Just-in-Time technology for certain premium products of Easy brew for assembling of product parts.The production process will enable customers to manufacture beer using latest technology. The premium products will be fully automated. Customers can select recipes from RFID tags of machines of Easy Brew. The products will brew beers with home delivered natural ingredients which will give the crafted beer its unique color and taste(Maier 2013). References Argent, N., 2017. Heading down to the local? Australian rural development and the evolving spatiality of the craft beer sector.Journal of Rural Studies. Gnauck, B., Hart, C. and Pagel, L., 2014. Blackrocks: Craft Brewing-From Hobby To Business: Applying Strategic Management To The Small Firm.Journal of Business Case Studies (Online),10(2), p.103. Hollensen, S., 2015.Marketing management: A relationship approach. Pearson Education.a Leschke, J., 2013. Business model mapping: A new tool to encourage entrepreneurial activity and accelerate new venture creation.Journal of Marketing Development and Competitiveness,7(1), pp.18-26. Maier, T., 2013.Selected aspect of the microbreweries boom.Agris on-line Papers in Economics and Informatics,5(4), p.135. McKeever, M., 2016.How to write a business plan.Nolo. Russell-Jones, N., 2014.Business Planning Pocketbook.Management Pocketbooks. Schaper, M.T., Volery, T., Weber, P.C. and Gibson, B., 2014.Entrepreneurship and small business. Thomas, D., 2013. Malting: the latest craft.Brewer Distiller Int., London, UK. Watne, T.A. and Hakala, H., 2013. Inventor, founder or developer?An enquiry into the passion that drives craft breweries in Victoria, Australia.Journal of Marketing Development and Competitiveness,7(3), p.54.

Wednesday, December 4, 2019

Huntington’s Disease Samples for Students †MyAssignmenthelp.com

Question: Discuss about the Huntingtons Disease. Answer: Huntingtons Disease Huntingtons disease (HD) is a dominantly inherited neurogenerative disorder resulting from the unstable expansion of the CAG trinucleotide in the HTT gene (Raymond, et al., 2011). The HTT gene serves as an instruction template for the protein huntingtin. The exact function of huntingtin is, however, unknown but it is proposed to play a role foetal development before birth, and also has a role in nerve cells (NIH, 2015). HD is a progressive disorder characterised by unwanted choreatic movements. Pathophysiology The expanded CAG repeat produces an extended polyglutamine tail on the huntingtin protein, and this causes the protein to cleavage and also generate toxic fragments (Jankovic Ashizawa, 2008). The polyglutamine content in the toxic fragments prompts cross-linking, and this forms aggregates that are resistant to degradation, and also causes interference with various normal cellular functions, predominantly mitochondrial energy metabolism, disrupted calcium signalling, abnormal protein interactions, transcriptional dysregulation of a variety of genes, alterations in axonal transportation of critical factors, autophagy, and altered proteasomal functioning (Zuccato, et al., 2010; Johnson Davidson, 2010). A reduction in the level of wild-type huntingtin has not shown to be contributing to the disease, it, however, magnifies the adverse effects of the generated fragments. The disease primarily affects the striatum, and the clinical presentation is primarily as a result of the damage (mainly cell loss and gliosis), include behaviour changes, cognitive impairment, and loss of coordination (Jankovic Ashizawa, 2008). Additionally, further pathological changes are also evidenced in several other cortical and sub-cortical structures (Rosas, et al., 2008). The hallmark feature of Huntingtons disease (chorea), results from striatal dysfunction. This pathological process is the most accepted and as a result, therapeutic interventions are being designed to improve mitochondrial function, facilitate retardation of apoptosis, enhance autophagic consumption of mutant proteins, block the cleavage of huntingtin at the sites that produce the toxic fragments, and also improve cell-cell interactions (Hannan, 2005). Existing treatments Drug therapy Neuroleptics such as haloperidol (typical) and olanzapine (atypical), benzodiazepines the monoamine-depleting agent tetrabenazine are used to suppress choreic movements (Huntington Study Group, 2006). While psychiatric disturbances that include depression are managed using psychotropic and antiepileptic agents (Frank, 2014) However, pharmacological treatment is only limited to the treatment of signs and symptoms and cannot change the disease development or progression (Killoran Biglan, 2014). Further, chorea may be exacerbated by L-dopa containing compounds (Warby, et al., 2014) Non-medication interventions Persons suffering from Huntingtons disease require psychotherapy from a psychotherapist to help in the management of behavioural problems, help the patient in developing coping strategies, and also manage the patients expectations through the disease progression. Speech therapy and physical therapy may also be indicated because HD can impair the control of muscles. A speech therapist will help the patient improve their ability to speak clearly, or in the use of communication devices. Physical therapy will help the patient enhance coordination, balance, flexibility, and strength. Persons with HD also require supportive care with special attention to nursing, diet, special equipment, emotional support, counselling, practical help and relief in forms such as state and federal benefits (Williams, et al., 2009). The primary inadequacy of non-pharmacological treatment is that it cannot be used as the primary treatment in the treatment of HD, but rather as secondary. Surgical treatment Surgical treatment plays a minimal role in HD. Surgical interventions are basically in the experimental phase and they include ablative surgery and cell transplantation (Demeestere Vandenberghe, 2010). These interventions show some promise but their efficacy has not been fully demonstrated. The primary advantage of surgical interventions is the possibility that they can modify the course of the disease. On the other hand, the primary disadvantage is that these procedures are that for the treatment of a widespread disease such as Huntingtons disease, the effects of the surgery tend to be confined to the local region where it is performed (Demeestere Vandenberghe, 2010). The impact on the individual health system of the disease and treatment Research on the economic cost of HD has not been well studied. There are only two notable studies on the same, one being conducted in the US (Divino, et al., 2013), and another in Europe (Busse, et al., 2011). The authors also claim that the primary cost in HD is the primary healthcare component. From the two studies, it is evident that the direct economic burden of the condition is substantial and it increases as the disease progresses. In 2013, the estimated cost for the treatment of an HD patient was $4,947 in the early HD stage, and this rises to $22,582 in the late stage, whereas in the UK, the earliest stages cost approximately 2250 per person and 89 760 in the later stages (Jones, et al., 2016). Other than the direct economic cost, HD has a significant impact on both the individual and their family. The onset of the diseases signs and symptoms is 35-45 years (Vamos, et al., 2007). This is the period when the family-life cycle is most complex, as characterised by childbearing and rearing and career development. The family suffers a great deal of distress and grief in the sense that they have to mourn those who have passed on and anticipated further losses for those who will die. Overall burden of disease It is estimated that 5 to 7 persons per 100,000 are affected by HD in the Western Countries (Australian Huntington's Disease Association, 2017). This is however not in the case as some regions of Western Europe have no HD whereas the concentration is quite high in others as evidenced in Lake Maracaibo in Venezuela where the prevalence is approximately 700 per 100,000 (Australian Huntington's Disease Association, 2017). As per the Australian Huntington's Disease Association, in Australia, approximately 1,800 people have the condition whereas another 9,000 are at risk. Its prevalence in Australia has been evidenced to increase at 15-20% per decade (Rawlins, et al., 2016). In the UK, it is estimated that 12 out of every 1000, 000 people are affected (Evans, et al., 2013), whereas in the US, 7 out of every 100,000 persons are at risk of developing the condition (Rawlins, et al., 2016). According to Rawlins et al., the lowest rates of HD are seen among Asians. References Australian Huntington's Disease Association, 2017. How Common Is Huntington's Disease (HD)?. [Online] Available at: https://www.huntingtonsnsw.org.au/information/hd-facts/how-common[Accessed 18 September 2017]. Busse, M. et al., 2011. Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study.. PLoS Curr. , 21(3), p. RRN1206. Demeestere, J. Vandenberghe, W., 2010. Experimental Surgical Therapies for Huntingtons Disease. CNS Neuroscience and Therapeutics, 17(6), pp. 705-713. Divino, V. et al., 2013. The direct medical costs of Huntington's disease by stage. A retrospective commercial and Medicaid claims data analysis.. J Med Econ., 16(8), pp. 1043-50. Evans, S. et al., 2013. Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records.. J Neurol Neurosurg Psychiatry, 84(10), pp. 1156-60. Frank, S., 2014. Treatment of Huntingtons Disease. Neurotherapeutics, 11(1), pp. 153-160. Hannan, A. J., 2005. Novel therapeutic targets for Huntington's disease.. Expert Opin Ther Targets., 9(4), pp. 639-50. Huntington Study Group, 2006. Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial.. Neurology, 66(3), pp. 366-72. Jankovic, J. Ashizawa, T., 2008. Huntington's disease.. In: J. Noweworthy, ed. Neurological Therapeutics: Principles and Practice. London: Martin Dunitz, pp. 2550-2561. Johnson, C. D. Davidson, B. L., 2010. Huntington's disease: progress toward effective disease-modifying treatments and a cure. Human Molecular Genetics, 19(R1), p. R98R102. Jones, C. et al., 2016. The societal cost of Huntington's disease: are we underestimating the burden?. Eur J Neurol., 23(10), p. 15881590. Killoran, A. Biglan, K., 2014. Current therapeutic options for Huntington's disease: good clinical practice versus evidence-based approaches?. Mov Disord, 29(11), pp. 1404-13. NIH, 2015. HTT gene. [Online] Available at: https://ghr.nlm.nih.gov/gene/HTT [Accessed 19 September 2017]. Rawlins, M. et al., 2016. The Prevalence of Huntington's Disease.. Neuroepidemiology, 46(2), pp. 144-53. Raymond, L. A. et al., 2011. Pathophysiology of Huntingtons Disease: Time-Dependent Alterations in Synaptic and Receptor Function. Neuroscience, 15(198), pp. 252-273. Rosas, H. D. et al., 2008. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity.. Brain, 131(4), pp. 1057-1068. Vamos, M., Hambridge, J., Edwards, M. Conaghan, J., 2007. The Impact of Huntingtons Disease on Family Life. Psychosomatics, 48(5), pp. 400-405. Warby, S. C., Graham, R. K. Hayden, M. R., 2014. Huntington Disease. In: R. Pagon, M. Adam H. Ardinger, eds. Gene Reviews. Seattle: University pf Washington. Williams, J. et al., 2009. The emotional experiences of family carers in Huntington disease. J Adv Nurs, 65(4), pp. 789-98. Zuccato, C., Valenza, M. Cattaneo, E., 2010. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev., 905(81), pp. 905-981.

Thursday, November 28, 2019

Martha Stewart Living Omnimedia, (MSO)

Introduction Martha Stewart Living Omnimedia (MSO) is a well renowned, brand name. When the Chief Executive officer is the â€Å"brand†, it can be difficult to separate their personality from the identity of the company they represent.Advertising We will write a custom essay sample on Martha Stewart Living Omnimedia, (MSO) specifically for you for only $16.05 $11/page Learn More The values of the company are bigger than those of the founder, this is evident from the continued success in fortune, especially after its founder was accused of business malpractices such as; insider trading. This was in contrast of what analyst had predicted. It is imperative for any company to take into account alternative strategies in enhancing personal and organizational effectiveness. External and internal elements of communication should encompass extensive research for better planning and implementation to identify, with common patterns of organizational behavior and consumer attitudes (Polk Wardwell, 2008). It would influence the strategy of sustaining its limelight, creating a competitive marketing strategy and restoring its image. Work Groups At MSO, teamwork within the work groups is emphasized to enhance multiple decisions; diverse experiences and collective judgment .For the team to exist individuals have to perceive themselves as part of the group. Thus, Martha Steward Living Omnimedia (MSO) in repositioning itself should take advantage of communication channels including social media to obtain customer feedback and build on them to improve its service and product delivery. Besides, through data obtained about employees should help the organization in identify areas to improve on. Rebranding, of any company is bound to fail if organization’s employees do not support it.Therefore, decisions made should incorporate suggestions from the people who identify most with the products. The effectiveness in employees’ performanc e enhances discipline, how employees relate with each other, their morale and instill motivation. Communications in a work group not only serve the need of informing, but also it is an important tool for controlling and an element of motivation. Therefore, for mutual and shared responsibilities among employees in the organization, effective communication in decisions made is critical for management at MSO to obtain positive feedback from their subordinates and other stakeholders. Communication The management should provide an elaborate communication strategy to strengthen performance and make employees feel part of the organization, become aware of ongoing trends and refute their fears about the organizations future goals. An organization is a society endowed with diverse employees of different backgrounds and culture. Hence, communication strategies are imperative in passing important organization information.Advertising Looking for essay on business economics? Let's see if w e can help you! Get your first paper with 15% OFF Learn More Top management at MSO has to identify fitting strategies in terms of management style, which can increase; employee’s motivation, creates satisfaction, and enhances organizations behavior and performance. In resolving disillusionment, and high expectations bestowed on them by the public, strategies such as; participatory management is essential in building trust, empowering and motivating an employee in performing tasks (Passikoff, 2006). Communication is therefore a key factor whether written or delivered orally. It is the only way; an organization’s stakeholders can express their expectations, suggestions, and any concerns or grievances they might have. In creation of a unique profile, proper communication input should emerge from the feedback obtained internally and externally. Rebranding Mason and Meyer (2006) indicate that rebranding as a process has direct impact on how the company is perceived by external environment. Change, as an element in shaping most organizations impact on all parties in an organization and major adjustments should be expected. The management at MSO in managing organizations crisis, resistance, and formulating important decisions will help to move in the desired growth direction. Rebranding a powerful brand like Martha Steward would be more destructive especially to the morale of many employees than it would be constructive and careful deliberations should be undertaken to protect employees from feeling alienated. Martha Steward heritage as to be factored during the process of rebranding. This is simply because it would seem like an effort to counter negative publicity more than its efforts to reposition or globalize the brand (Passikoff, 2006). Although many other companies like Pepsi or Google have been successful in rebranding themselves, the rebranding of Martha Steward would be a move from a more individualized to a cooperate feel than many co nsumers might not identify with. Instead, it should concentrate on striking a balance in building an identity from the individual and taking advantage of the appealing Martha’ public image. Conclusion Marketing strategies of an organization can be hinged on its branding and communication among other important strategies. These factors are important in enhancing the organizations’ consumer perception and forming strong collaborative partnerships with similar competitors. These strategies are not only important in enhancing organization services, and products, but also leverage an organization against its competitors and enhance employee’s morale.Advertising We will write a custom essay sample on Martha Stewart Living Omnimedia, (MSO) specifically for you for only $16.05 $11/page Learn More Reference List Mason, A. Meyer, M. (2006).Living With Martha Stewart Media: Chosen Domesticity in the Experience of Fan. Journal of communication, (51),pp. 801-823 Passikoff, R. (2006).Predicting Market Success: New Ways to Measure Customer Loyalty and Engage Consumers with Your Brand, New Jersey: John Wiley Sons Inc. Polk, R. Wardwell, L. (2008). A Comparative Study of  Insider Trading  Regulation Enforcement in the U.S. and China Journal of Business Securities Law, (9), pp. 56-63 This essay on Martha Stewart Living Omnimedia, (MSO) was written and submitted by user Collin Collier to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Google in Corporate Business World

Google is one of the greatest success stories in corporate online enterprise. The growth of the company from a humble enterprise to a multinational company turning over millions of sterling pounds is a feat that only a committed business-minded collaboration can achieve. The company has established online presence in various areas including search engine, social networking, messaging and service in data centers.Advertising We will write a custom report sample on Google in Corporate Business World specifically for you for only $16.05 $11/page Learn More This presentation has analyzed both the company’s business and leadership strategies in the light of other approaches that could have been used to warrant such tremendous success. It has been well established that the transformational leadership style that was embraced is best suited for the kind of business that Google is involved in. This strategy should therefore be maintained even in the wake of the paradigm shift facing the company. An internal review has been conducted for the company and this generally revealed the strengths, weaknesses, opportunities and threats to the company have been critically highlighted. It has been realized that some of the company’s greatest strengths include a well established brand name through the provision of reputable services as well as proper market capitalization. By the company ensuring that the usage of the website accords them interactivity and is easy to use, Google has consistently triumphed over competition. These benefits are spread by word of mouth and this by extension contributes to the growth of the company’s reputation. The weaknesses that have been touched on include the fact that the company has been overly dependent on the search engine for almost all its financial benefits while the rest of the services it invests in yield nothing in return. One of such unprofitable ventures include Youtube which provides r eceives massive daily traffic but does not bring any returns to the company. Another weakness that has been established is the vulnerability of Google to spam attacks. Even though the company invests a lot in ensuring that spam and other related attacks are kept in check, the rapidly occurring changes in information technology see the creators of such malicious content carry the day by coming up with more elaborate versions of spam.Advertising Looking for report on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More The identified opportunities available to the company include the venture into android software- a factor that has been necessitated by the gradual shift of the internet to mobile devises. However, with such opportunities come even greater threats. The company is now prone to law suits emanating from privacy issues and censorship authorities. Other threats include the rise of competition from other internet giants such as Yahoo and Microsoft. The creators of online libraries are now starting to be more protective of their content and can configure it in such a way that it is not accessible via Google. This has seen users migrate to other ways of conducting data searches gradually ‘stealing’ clients from Google. Aside from this, an external review of the company was also done and it listed some of the factors outside the company that have made Google achieve the immense success it has so far. These include the fact that the company has grown into a strong supplier of online advertising space and has gone ahead to capitalize on this venture to its advantage. The loyalty that the company has attained from its clients has also been regarded as having contributed to its ability to deal with competition. The company’s business model, its strategies and future outlook were also assessed in light of the challenges that the company has to contend with on a day to day basis. The co re competencies of any company always end up reflecting on its overall success. The consistent development of new products and the establishment of a proper human resource framework have immensely increased Google’s innovative and visionary approaches. The company’s culture where all individuals are allowed to present their opinions without discrimination has turned the establishment into a cohesive environment which in turn translates into greater staff output. This report has elaborated on the various features of the strategies adopted by Google using extensive literature drawing from the works of various scholars. It is important to note that this strategy works for the company and should therefore be reinforced by the various other strategies that have been discussed in this report. It would be unwise for the enterprise to completely abandon a working strategy due to the current transformational changes facing the company, for another that has not been tried and te sted for the same market.Advertising We will write a custom report sample on Google in Corporate Business World specifically for you for only $16.05 $11/page Learn More In conclusion, it is worth noting that the Google Company has over time come to be a force to reckon with in the corporate business world. As has been noted above, the successes of the enterprise draw from its strong managerial framework and innovative approaches in making the interface user-friendly. With the kind of financial supremacy that the company has at the moment, it is likely that it will continue its unrivaled ascent to success in the foreseeable future and still maintain its position at the top of the search engines’ ranking. This report on Google in Corporate Business World was written and submitted by user Daphne Rush to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Monday, November 25, 2019

election 2000 essays

election 2000 essays It is finally over, probably the most common statement you would hear if you asked any U.S. citizen their thoughts on the presidential election of 2000. This election was definitely the closest of any presidential election recorded in history and believe me when I tell you it will not be forgotten. There are mixed opinions on the outcome of the election, Democrats say that all the votes should have been recounted and that if they were, Vice-President Gore would have won after all. The Republicans are saying that Vice-President Gore knew he had lost from the moment that Floridas votes were counted and that he just could not except the fact of losing. But in my opinion like most political events, the 2000 presidential election has produced a number of false premises and has inflicted damage upon our constitutional system for the foreseeable future. The largest problem I feel with this election was that it was ultimately settled by the Supreme Court of the United States, a body that should never been called upon to end this election. If you read most of the opinions posted in the media, critics have put most of the blame on George W. Bush. They say he was the one who appealed the decision to the Florida Supreme Court in Washington and determined the final verdict. But I think that in all "fairness" - a word that was thrown around so arbitrarily by the Democratic Party, that it was the Florida court that forced the U.S. Supreme Court to get involved. Neither of the candidates can be held responsible for that decision. Another issue I would like to address that I feel has caused hysteria in the decision of this election was the recount of Floridas votes and their deadlines. I think that if Floridas votes were to be recounted, as they were, all counties had to participate, not just the targeted ones. I also think that the mandatory deadline that was put in place was properly instated ...

Sunday, November 24, 2019

The origins of homophobia and the power the NSW Government is able to exert over sexuality.

The origins of homophobia and the power the NSW Government is able to exert over sexuality. What control is the state able to exert over sexuality, and how is this done? Discuss with reference to homosexual identity for young people.Discrimination remains a reality for members of the gay, lesbian, bisexual and transgender (GLBT) communities in NSW. Homophobic prejudices that fuel this discrimination are often unfounded but draw strength from the discriminatory law itself. This essay is going to analyze how the state exerts control over GLBT people and what this entails for the GLBT community. But before looking at how the NSW government excludes members of the GLBT community from fundamental human rights, this essay is going to discuss how homophobia arose in the first place.Given the fact that Christian beliefs are deeply embedded in Australian society it is obvious that the Church contributed to the formation of homophobia. For thousands of years the church had been instructing society on what was moral in sexual matters and homosexuality was not on their list.Jonathan Co ulton at Game City zombiefestHomosexual attitudes were regarded as absurd and seen as a crime against nature. In 1977, Anita Bryant, an anti-gay campaigner said that "God created Adam and Eve, not Adam and Steve", adding that "homosexual acts are contrary to the laws of nature and the protesters must realize that the Church's teaching on this matter cannot, and will not change". The Church's current standpoint on this matter is that members of the GLBT community are 'tolerated', but only if they are 'discreet'. However, Bishop Benjamin Tutu of South Africa once pointed out that homosexuality cannot be a matter of choice. Who would select a life style that would bring such hatred, abuse and discrimination against them?On the other hand, homosexuality has been a tolerable practice within Christianity for centuries. Michelangelo and Leonardo da Vinci were famous homosexuals, and religious personalities. Where...

Thursday, November 21, 2019

Statistics COMPREHENSIVE Essay Example | Topics and Well Written Essays - 1750 words

Statistics COMPREHENSIVE - Essay Example Therefore nominal data where attributes can be ranked but the distance between ranks has no meaning. c. interval data- in this level of measurement the distance between ranks has a meaning, data can be ranked and at the same time the distance has meaning, for example temperature data is interval data where temperature difference has meaning. The average and median calculated has a meaning but ratio calculations have no meaning where one cannot state that 100 degrees Celsius is twice 50 degrees Celsius. d. ratio- in ratio level of measurement the absolute zero value has a meaning, all statistical calculation of central tendencies and dispersion are meaningful, for example data containing number of customers that visit a retail shop, the value zero has meaning and the ratio calculations also has meaning where it can be stated that 20 customers is twice 10 customers. The mean, mode and median are all measures of central tendencies of data; the mean is determined by adding up all the values in a data set and then dividing the number of observations. In the example the value of the mean will 27/8 = 3.375 The Median is the middle value of an ordered data set for odd observations or the mean value of the middle two variables for even observations. In the example the median will be 3 +4 = 7, then 7/2 = 3.5, therefore median = 3.5 Advantage: The median is not affected by

Is it more important to hire employees with the right personality Essay

Is it more important to hire employees with the right personality characteristics, or to try to improve their job-related attitu - Essay Example The personal character will entail the individual’s interest for the job and whether he will be suitable for the particular job or not. If the candidate is hired without proper judgement of his personalities, then the appropriate candidate will not be selected since the candidate’s attitude towards the job can change. The goal of this assignment is to understand the importance of personality of an individual during hiring process. The different ways by which the personality character can influence the work in an organisation will also be studied. The study will also look to find out whether it is more significant to hire employees with right personality characteristics or an employee’s job related attitudes can be improved once they have joined an organisation. From this paper, it can be learnt that the proper judgement of personality characteristics during hiring process is a vital factor. This paper helps to find out different personality characteristics that b ring positive as well as negative attitudes during interview session. 2.0 Review of Literature Recruiting and hiring decision is complicated, thus it becomes challenging task for the company to hire a quality employee. The recruiter must be certain that the hired candidate performs best to their ability and acts as a value addition to the organisation (Profile International, n.d.). Recruiters use personality test in order to enhance their decision making process about the prospective applicants. When the information is large, the recruiter can be more capable and accurate with the appointment of the candidate. A person’s personality can determine whether he or she can work attentively, intelligently, optimistically and cooperatively. The style or manner in which a person approaches his or her work is influenced by the personality. The working style of a person matters a lot because unhappiness, rudeness, moody nature may affect the workplace as well as morale of the employees . Personality is considered as one of the most significant factors while recruiting and hiring an employee. The personality characteristics of a potential employee can determine his performance within the business boundaries; and cooperate as well as interrelate with the existing staff members. A positive personality may boost the morale of the entire staff, resulting in increased productivity and success in the organisation. The employees who are not screened properly during interview or hiring process are more likely to face negative consequences such as get fired for their improper conduct in the organisation (Hogan Assessment System, n.d.). Personality of an individual also includes measurable traits of behaviour that facilitate how an individual can perform in particular situation in the organisation. By understanding the personality characteristics the recruiter can hire the desired candidates. Job match is the extent to which the employees have the cognitive skills, interests and quantifiable personality traits that are essential in performing the job effectively. The four personality types are generally identified which encompass stable, dominant, influencing and compliant. The core personality characteristics are critical to examine the ability of candidate while performing any job (Swenson, n.d.). If the hiring of the candidate is done in an

Wednesday, November 20, 2019

Comparing Criminal Justice Systems Assignment Example | Topics and Well Written Essays - 1000 words

Comparing Criminal Justice Systems - Assignment Example As much as criminal justice systems of all countries seem to follow some universal devising justice and punishment, there are wide variations between countries in the ways that these approaches work. This is because of the differences in power of law enforcement, style of policing, limits of search and seizure, the doctrine of presumption innocence and the doctrine of reasonable doubt. Other factors that create differences among criminal justice systems across countries include protection of self-incrimination rights, exclusion rules and other intra-systematic processes in criminal justice, which are not valued and practiced in the same way in every country. In this report, a comparison of criminal justice systems, based on the cases of Amanda Knox and Michael Fay, two young U.S. citizens accused of crimes in other countries, illustrates the differences between the U.S. criminal justice system and those of Italy and Singapore. The Knox case is a murder case, which is about the murder of a British student, Meredith Kercher in Perugia, Italy. During the time of the crime, all the occupants of the cottage had left to spend their night elsewhere apart from Meredith Kercher, who was to spend the night alone in the cottage. On the following day, Knox and her boyfriend, Rafaelle Sollecito, discovered that one of the windows of the cottage, where Meredith, Knox and others lived, had been broken. They called the police. The police forced the door to Kercher’s bedroom open and it was discovered that Kercher had been murdered. Knox and Rafaelle were accused of murdering Kercher because the deceased had refused to participate in a sex game. Knox’s boss was also accused on the same account, but he was released upon lack of evidence linking him to the crime. Forensic evidence led to the arrest, prosecution and conviction of Rudy Guede for murdering Meredith. On the other hand, Michael Fay was sentenced to four months imprisonment and six strokes of cane because

Defining the Word Hot Essay Example | Topics and Well Written Essays - 750 words - 6

Defining the Word Hot - Essay Example Perhaps the primary reference of the word hot is a high temperature. During the summer, weather temperatures could go as high as a hundred degrees Fahrenheit or even higher. In Dubai, it has recorded 122 degrees Fahrenheit high. This is an extremely high temperature for humans and animals so that they need to stay indoors more often and have relied on air-conditioners to lower the temperature. When people need to go out, they should have something to block them from the sun such as an umbrella and they should also carry water to quench their thirst brought about by the high temperature. Obviously, the heat of the sun is a big factor affecting this hot temperature during summer. With no clouds to block the sun, the earth’s direct exposure to it elevates the temperature and therefore makes people perspire as a result of the hotness of the atmosphere. Similarly, hot is often associated with fire which is used to cook food or to make the house warm during winter.  Secondly, the word hot can also refer to a person’s hot-headedness. This association is most probably based on the fact that an angry person has an elevated blood pressure that causes his face to become red especially with white men. When a person is angry, his heart beats faster and pumps blood more rapidly which explains the increased blood pressure. Consequently, the temperature of the man also rises like a person suffering from the fever so that, in relation to the discussion above, an angry person is called hot. The process allows more blood on the head and changes the color of one’s face. Therefore, this could also be associated with the blood. Blood and the heart are identified with the color red. Moreover, a fire which emits some reddish glow or the color of ember or glowing coal is red. Blood, heart, and anger are all interconnected and this is the reason why an angry person is also referred to as hot-tempered. The term is the opposite of the slang word â€Å"cool†.

Monday, November 18, 2019

Legal Aspects of International finance Essay Example | Topics and Well Written Essays - 1250 words

Legal Aspects of International finance - Essay Example Stock is the type of equity security with which most people are familiar. When investors (savers) buy stock, they become owners of a "share" of a company's assets and earnings. In other words, the companies borrowed directly by issuing securities to investors in the capital markets. By contrast, indirect finance involves a financial intermediary between the borrower and the saver. Emerging market bonds is a Security markets in countries such as Mexico and Malaysia that are still developing their industrial base. Investments in emerging markets entail substantial risk with the potential for above-average returns. The direct or indirect benefits of international trade and finance come primarily from the enlargement of the market and the specialization and more efficient employment of productive resources, as well as technological advances. International transactions involve covenants agreed upon by different countries. The discussion of the paper is about the covenants involved. Debt covenants, also called banking covenants or financial covenants, are agreements between a company and its creditors that the company should operate within certain limits. Debt covenants are agreed as a condition of borrowing. They may be changed if debt is restructured.(www.moneyterms.co.uk). One of the importances of debt covenants is that it can impose heavy obligation. Companies are careful in dealing with the covenant; breach of a debt covenant allows creditors to demand immediate repayment. A breach of covenants usually leads to a renegotiation of the terms of debt. In order to prevent companies from meeting the requirements by adjusting their accounting practices rather than by genuinely maintaining the required level of financial health, debt covenants not only specify the numbers that should be met, but also exactly how they should be calculated for the purposes of the debt covenant. This means that if a company breaches, or is in danger of breaching its debt covenants, not only does this indicate that the company is not financially strong, but also that the problems are likely to become worse as lenders react. The following are reasons why covenants are important: (Noonan, 2005) 1. Covenant protect bondholders against a diminution in value of their investment through: Credit deterioration Loss of "equity cushion" Loss of control over assets Loss of seniority position 2. Covenants increase the chance of capital gains for bondholders because they force the company to Deleverage (or, more accurately, limit the company's ability to releverage) Reinvest earnings The typical restricted payments covenant requires the company to retain 50% of net income in the business and allows 50% to be dividended out to to stockholders 3. As a result, covenants lead to credit improvement which increases chance that bonds will trade above par High Yield Debt Covenant Optional Redemption - Most issues of tax-exempt bonds have "call protection" wherein the bonds may not be called (i.e. redeemed) by the issuer for a specified period after the date of issue. A typical call protection period on a 30 year bond is the first 10 years after the issue date. After the initial period, many tax exempt bonds contain optional redemption provisions which permit the issuer to call the bonds prior

What are the pros of unification on East Germany Essay

What are the pros of unification on East Germany - Essay Example Germany rose in the international politics and became the largest and strongest country economically, in the European Union. This political stability could be seen in the nature of elections and policy processes that took place in the country. The state ensured that the citizens participated in the countrys political affairs. The government educated the citizens on political systems, making them aware of their role. Policy making processes became transparent with the interest of the citizens at heart (Dalton et al). Introduction of a functioning currency (Deutschmark) was an economic benefit to the country. In addition, stable administrative and legal systems attracted investors in the country. Thus, Germany had access to European markets and funds. Between the years of 1990 and 2006, the European Union had given 17.9 billion Euros to Germany. These funds have assisted the country dealing with the economic and policy challenges (Dalton et al).

Friday, November 15, 2019

Internal and External Analysis of Franchise

Internal and External Analysis of Franchise Penny Thomas, an Ivey graduate with the help of her daughter, who also is an Ivey graduate, decides to purchase a license to open a Marble Slab franchise in the Great Toronto Area. After paying her fees of $25,000 to the company, she starts thinking of her marketing plan for her grand opening that she has two weeks to hand to the Marble Slab head-quarters in Calgary . So she hired a marketing consultant (me) to help her. First, the corporate capabilities of the company had to be defined, financial capabilities, Marketing capabilities, Operational capabilities and the available human resources. After comprehensively studying the internal capabilities of the company, the external forces affecting the business are analyzed. The two external forces categories discussed in the report are the economical factors in the area, the social factors. Politically and technologically didnt have an effect on the business. After that, the direct and indirect competitions of Thomas were examined and t hen plans were made to compete with them. The direct competitions were Baskin Robins and Dairy Queen. The indirect competitions were McDonalds, Star Bucks, grocery and convenience stores. After carefully examining all these influential forces, a consumer analysis of the three best potential target markets were women, young adults and families was set up. And the target Market of Women was found most suitable for Thomass business because women are the primary caregivers, dominant shoppers in the community and they are more health conscious than males. Once the target market was chosen, a marketing 4Ps plan was constructed. Product wise, Marble Slab franchise had plenty of options to choose from, from milk shakes to ice cream cakes. But the primary product that Thomas should use while promoting the grand opening is the Childs size ice cream with one mixin because it is popular and it appeals to womens concerns because it is small and tasty. Then prices were determined for only caterin g, because Marble Slab is a franchise and it wasnt allowed for Thomas to change any of the prices. She only had power over the catering prices, so calculations of the breakeven points of the three different catering options were conducted and the best catering choice was the Sundae Bar option. After that, the location of the store was determined by studying each areas population and traffic. And the area that was chosen was the Toronto Annex area, although with a low population, it had a lot of foot traffic from students (almost half of students being female) and near a busy shopping street. Following the location of the business, different promotional options (billboards, radio, etc.) were examined and the most suitable, affordable combination of promotions for the grand opening were chosen. In conclusion, this marketing situation was studied comprehensively and the following results of the marketing report project that the grand opening is going to be successful along with the yea rs to come. The Marble Slab Creamery has been a well-known name in the market for ice cream since it first opened in Houston, Texas in 1983. Now Marble Slab has 400 branches worldwide in which, Penny Thomas had been blessed to be a part of when she purchased the right to open up a franchise in the Greater Toronto Area. Thomas is going to have a grand opening in May 2008 and needs a marketing plan to get approved by the headquarters in Calgary, Alberta about how she will handle the grand opening. The following marketing report breaks down the corporate abilities and the external analysis of Thomass company, also it discusses the consumer analysis and the competitive analysis. After deciding on the right target market, the report discusses Marble Slabs marketing plan which include product, price, promotion and placement. Corporate Capabilities: Marble Slab enjoys many financial abilities, being one of 400 franchises; Penny Thomas shares the same purchasing power of the franchisor. This is really helpful because Thomas would get a great deal of help from the Marble slab company by providing penny with connections that she can use to increase the store’s success and it would save her time now that she got all the connection and purchasing power she needs. Another ability and privilege that comes with a franchise is that the financial risk of any financial disaster is reduced and the consequences wouldnt be as severe because the store is backed up by a large well-established company that acts as a safety net for Penny Thomas’s store, which is helpful and the store can feel more secure. On the other hand, marketing budget was set at $10,000, which can cover all the costs of the grand opening adequately, which is good for the starting company because budget is tight for any new project and e fficiency is a key player in making the starting of this store follow more smoothly. Marketing capability wise, Penny Thomas enjoys Marble Slabs already existing prominent name, so the store isnt a new store that the target market must discover and learn about. Therefore, the franchisor made Thomas’s promotional task easier, and many existing Marble Slab customers will come to this location. As well, Marble Slab is already known for its high quality products that many customers around the 37 Ontario locations enjoy and crave. Thomas’s operational activities offer a great deal of mainly quality, freshly made ice-cream, with the option of letting the customer customize their purchases with a choice of toppings blended into their ice-cream flavour of choice, these choices include fruit pieces, candy and specialty nuts. These blends were made by a Marble Slab employee on a marble granite slab it also serves kosher, low-diet frozen yogurt, sundaes, floats, soft drinks and i ce-cream cakes. All these activate differentiate Marble slab from any competition giving them a competitive advantage that leads to more sales. Moving on to human resources, Thomas is blessed with the degree from Richard Ivey school of business, help of her daughter who also graduated from Ivey and valuable 25 years worth of experience working for the Hudson Bay company and she was familiar with her father’s past AW restaurant that he owned. This helps her greatly, because she knows what to expect and she is a very wise women in the field of business. She is also enjoying the expertise and network of the Marble Slab’s company, that helps her get started with the help of her network and make her avoid wrong decisions that were made in the past. Marble Slab’s employees must be well trained to handle all the machines and blending techniques so they can achieve the whole Marble slab’s experience that the customer expects. Employees are also highly hygienic be cause the work requires lots of hand work. External Analysis: The economy this year is going through a difficult recession in the United States. Which raises fears on how the Canadian economy will get affected later with the decline in Canadian exports and the commodity prices, only one wonders how the recession will hit Canada. But the consumer spending and the Canadian GDP are still growing. This instability raises fears for the business, maybe hurting it in the future because if the recession does hit, less consumers will be able to afford the quality of Marble Slab so sales will decline. Also because Marble Slab deals with dairy products, cocoa and sugar commodities, in which always fluctuate in price and never stable depending on supply and demand of the market. That may hurt or help the business because prices might fall to less than expected, increasing the marginal profit or increasing to more than expected, decreasing the marginal profit. Socially, Thomas’s business is expected to decline in winter months, bec ause of Canada’s long harsh winters, because less people get a craving for good ice cream in the winter months than in the summer. Ice cream is also became a popular snack within the people, with the average Canadian consuming 8.4 litters annually in 2007. Also, the companys good quality products give the store an advantage of having people to like to show off in a way Marble Slab’s ice cream while they are eating it with their friends. Also, there is growing health a trend growing that pushes people to look for healthier ways to snack such as frozen yogurt, in which Marble Slab’s serves their customers. Competitive Analysis: Marble Slabs direct competitions in the market are Baskin Robins and Dairy Queen. Baskin Robins always had a strong presence in the Canadian Market. They have their stores present in good locations with high traffic for customers convenience. They serve 31 original high quality flavours, with the same price range as Marble Slab. Baskin Robins also enjoys a fortune of resources and promotional power. Though Baskin Robins has all these features, they dont give their customers the option of customizing their purchase like Marble Slab does. Marble Slab can compete with them by keeping the prices in the same range while emphasizing to the target market the option for customers to customize their purchases. This way Marble Slab would have a competitive advantage over Baskin Robins. Baskin might respond to this by introducing the same option we offer or decreasing their prices. The other direct competition to Marble Slab is the world-wide restaurant of Dairy Queen, whi ch served the same category of products with the option of customized purchase to their customer as marble slab does, but Dairy queen also sells hot food items such as hotdogs, burgers and fries. On top of that, they targeted the family markets because they also offer friendly-kid options. Dairy Queen is present in high traffic areas such as malls. Marble Slap therefore, has to try to avoid competing with Dairy Queen by targeting a market other than families, and at the same time focus on the quality of Marble Slabs products and show customers that they may be paying more but the quality they are gaining is much more than Dairy Queen. Dairy Queen might respond to this by increasing the quality of their products and focusing on the hot foods that they serve and promote it more to attract more customers. For competitive positioning map (see Exhibit #1). In addition to Marble Slabs direct competition, Marble Slab has three indirect competition; McDonalds, Starbucks and Grocers and convenience stores. McDonalds is the worlds largest fast food chain restaurant. Other than hot foods, they offer soft-serve dessert items such as ice cream, milk shakes and the Mcflurry. McDonalds is present in high traffic areas and offers a drive thru for customers in a hurry. They have cheap prices that anyone can afford in Canada, but also serve low quality products. McDonalds may seem like tough competition but it is not because it serves limited options for its customers. Marble Slab should focus on their quality and the unique Marble Slab way of making their products and making it more accessible for customers by adding a drive thru option. McDonalds wouldnt respond because their main goals arent about frozen desserts, they care more about their hot foods. A second indirect competition to Marble Slab is Starbucks, which is a premium retailer of coffe e dessert and fresh food items. Starbucks gives its customer a cozy atmosphere and wireless internet. Like Marble Slab, it offers high quality products for premium prices. Marble Slab already serves better quality choices and options of ice cream which gives a competitive advantage to Marble Slab. Marble Slab can also compete with Starbucks by giving the same cozy atmosphere in the restaurant but also suitable for younger children. Starbucks will respond to this by introducing new drinks which will appeal to children. The third indirect competition is the mass produce ice cream companies that distribute to grocers and convenience stores. These products appeal to a lot of people because they vary in prices and they are really accessible for customers because they are sold in grocery or convenience stores. Problem with this is that they are not always fresh and full of ingredients that keep the product fresh which can be harmful to the customer. Marble Slab can compete with this by se lling their mixes and their ice creams at a number of grocery and convenience stores in the future. For competitive positioning map(see Exhibit #1). Consumer Analysis There are three target market options that will probably appeal to Marble Slab, families, young adults and women. Families with children under 15 years of age are the best potential customers. Children represent the bottom of the population pyramid, which means that they are more than any other target market. Families eat ice creams when they go out with their children and the children ask their parents to buy them ice cream to satisfy their sweet tooth. Families are willing to buy mostly on weekends at locations near parks while taking the kids out, and inside malls while shopping. The second target market are young adults that age from 15-24 years of age who have some or full independence, and can spend their disposable income on social interactions. Young adults find ice cream a popular after a long day at work or at school or just simply to chill out. Young adults are influenced to buy from Marbles by seeing famous people or their idles eat Marble slabs Ice crea m. Young Adults would purchase an ice cream from shopping centres while they are shopping or beside a high school or a college when they are on break or after class. As good as the young adults target market sounds, it is very competitive because there is already a lot of ice cream outlets targeting this group. Which leads to the last target market†¦ Women, which are the best target Market for Thomass Marble Slab creamery. Because women are the caregivers and dominant grocery shoppers in our society, they also do more shopping than men in general, and they are more health conscious, which is good for the stores low-fat snacks. Women are influenced to purchase from Marble Slab when seeing skinny models satisfying their taste buds by enjoying their tasty Marble Slab snack, while still keeping their bodies fit. Women are everywhere, they can purchase from shopping malls, streets, gyms, parks and colleges at any time of the day, any day of the week, but mostly weekends. And women s pend alot of time at malls so Marble Slab would be a great snack for them. 4Ps {Product} Marble Slab is a franchise that differentiates itself from other ice-cream outlets because it serves their customers high quality, top of the line products. With the option of customizing their purchases by choosing different flavour blends and mixins which included, fruit pieces, candies and specialty nuts. Mixins were blended by employees on a marble granite slab. Also Marble Slab offers Kosher for the Jewish customers and a wide variety of different milkshakes, frozen yogurt, sundaes, milkshakes, floats, ice cream cakes, soft drinks and newly added fat-free frozen yogurt. The product that Thomas should focus and promote the most is Childs size ice cream because it is fairly popular and it appeals to her target market which is women, because it is a small portion with less calories and very tasty. {Price} Marble Slab is a franchise; therefore it doesnt have any power of changing of prices.(For unit contributions of products see exhibit 3) It requires Thomas to sell 7764 units of Childs size ice cream to break even and start making a profit. (see exhibit 2). Childs size ice cream is the product that will be promoted with the promotion of the grand opening, because it appeals to womens needs; its small and tasty. But the company gave Thomas the flexibility of prices in catering. Thomas should choose the Sundae bar catering option because it gets the most profit selling less units to break even than the other options. Sundae Bar needs 57 customers to breakeven the costs while the Ice Cream social needs 59 customers to break even and start making a profit.(see exhibit 4) The portable Slab option is unaffordable because there is only $685 left from the $10,000 budget that was set for the promotion, and $2,500 are needed for additional equipment.(exhibit 5) Thomas should keep her pr ice at the average which is $6.95 per person because price wars may lead to bankruptcy and because she is located in a busy area beside a university and a shopping street. Therefore, will get a lot of catering offers because it is where a lot of students and women who are either shopping or hanging around or at university would probably come and party on birthdays and other occasions. {Placement} Thomas should open her Marble Slab restaurant in the Toronto Annex Area. Although it has a smaller population of any of the four options, The Annex area has a lot of traffic from the university that is there and it is very close to Bloor Street, which is a major shopping street. This location is the most appropriate for the Creamery because Thomass target market is women. And women are the primary shoppers in society and the university probably has a high percentage of females attending it. So this location is located in the heart of where many women walk for either shopping or going to class. The location will also help have a more successful grand opening because it is exposed to people who go thru that busy area. {Promotion}To effectively promote the new store for the grand opening, Thomas should spend $2,120 on two street level media unit, in the Toronto Annex area , because the street media would be exposed to the people shopping and in university, showing them that a light, low fat snack from Marble Slab would be delicious while shopping or after class. In addition, Thomas should purchase two 10Ãâ€"20 feet billboards costing $2950 that would be located in high traffic roads. These billboards and street media should show a visual image of the creaminess, lightness and taste of a super premium Ice cream, preferably a childs size ice cream with one mixin, because it is small in calories and it would be best to promote. The advertisement will have a beautiful athlete physically-fit model eating from it. That way it will appeal to the target markets taste buds and show that you can stay healthy and fit while still eating delicious food. Thomas should also spend $645 on a daytime radio commercial for 30 seconds and $650 on a radio commercial at breakfast time. Thomas should purchase those times because morning time is the most time that people tune in to listen to the radio while they are eating breakfast or driving to work. And the other commercia l at daytime is effective, because it is when most people are awake and thinking of things to eat to get on with their day. Both types of promotion should emphasize the good quality, freshness and low fat in Marble Slabs products. All this adds up to $9315, which is less than the budget of $10,000 with an excess of $685. (See Exhibit 5) Confidently, this report will satisfy Penny Thomass wants and needs. This report discussed in detail the corporate capabilities, consumer analysis, competition analysis and the external analysis of the franchise. And from studying all these factors, the most suitable product, location, price and promotion were chosen for the grand opening of this franchise within the budget of $10,000. In conclusion, this marketing plan was designed to boost the businesss success from the start of the grand opening and for the many years to come. Surely, the Marble Slabs headquarters will approve of this report and would be anxious to see the results when the grand opening is on May 2008.