A Brief Description of Schizophrenia - 1135 Words

According to schizophrenia.com schizophrenia is a complex, debilitating mental disorder that 1-2% of the world population experience. It is a disorder of the brain that affects how people think, feel, and perceive. The purpose of this paper is to explore schizophrenia, in particular its signs, symptoms, etiology and pathophysiology, and then examine drug treatment and their mechanism of action. This will be followed by the prognosis for people with schizophrenia. Signs and Symptoms Early signs of schizophrenia include personality changes that involve abnormal emotional responses, mood disturbance, or depression, as well as cognitive changes (Schizophrenia Society of Canada, 2012). Symptoms of schizophrenia can be classified as positive†¦show more content†¦Dopamine Hypothesis The current dopamine hypothesis suggests that schizophrenia is a result of dysregulation of dopaminergic activity – there is an increase in dopamine D2 binding sites and there are prefrontal D1 deficits (Moncrieff, 2009;). This means that there is over activity of dopamine in certain areas of the brain – possibly leading to positive symptoms – and there is also under activity of dopamine in other areas of the brain – possibly leading to negative symptoms. The original dopamine hypothesis claimed that, rather than dysregulation, there was simply too much dopaminergic activity (Moncrieff, 2009). The dopamine hypothesis came from identification of antipsychotics as dopamine D2 receptor blockers (Nord, Farde, 2011; Miyake, Thompson, Skinbjerg, Dargham, 2011). Schizophrenia has been associated with the dysregulation of additional neurotransmitter systems such as serotonin and glutamate (Moncrieff, 2009). Drug Treatments Antipsychotics have long been the primary drug treatment for schizophrenia (Lehne, 2010). Antipsychotics are split into two main groups: 1) first generation antipsychotics (older, conventional); and 2) second generation antipsychotics (newer, atypical). First generation antipsychotics (FGAs), such as haloperidol are dopamine D2 antagonists. The most common side effects include increased prolactin levels and extrapyramidal effects. Second generation antipsychotics (SGAs), such as clozapine, areShow MoreRelatedA Brief Look at Auditory Hallucinations1332 Words   |  5 Pagespsychosis, specifically schizophrenia, but are also featured in a minority of people that do not have a mental illness. Auditory hallucinations have been known to cause distress in patients that have not found ways to cope with the voices in their head. Internal voices may give the individual a negative or a positive association; most individuals with schizophrenia tend to have negative experiences. As defined by Christos Ballos in an article in the New York Times, schizophrenia is a disorder that isRead MoreSchizophreni A Psychological Disorder1028 Words   |  5 PagesHill College December 7, 2016 Assessment Research paper Schizophrenia is a psychological disorder which about one percent of the population (John et al., fid. 2001) Morbidity is caused by the negative and positive symptoms. Research has shown that disability and impairment is caused by cognitive impairment in schizophrenia. It is by a group of disorders which and it s largely unknown. It involves a set of disturbances of perception, thinkingRead MoreSymptoms And Symptoms Of Schizophrenia1343 Words   |  6 Pages What is Schizophrenia? Experts agree that it is a syndrome (signs and symptoms that are thought to co-occur in ways that distinguish it from other syndromes and from normal thoughts and behaviors). Schizophrenia is also defined as a psychotic disorder with, impairments in reality, disturbances of perception and thought experienced as hallucinations, delusions, hearing voices, seeing things that are not there, and paranoia. Its onset usually starts in a person’s late teens to early twentiesRead MoreAtypical Antipsy chotics.A Brief Overview. Dr. Vipin1114 Words   |  5 Pages A BRIEF OVERVIEW Dr. VIPIN KUMAR, MBBS, DTCD, MD (PSYCHIATRY); CONSULTANT PSYCHIATRIST, AURANGABAD, BIHAR The atypical antipsychotics or second generation antipsychotics (SGA) are a group of antipsychotics that were introduced in the clinical practice during the early 1990. All over world these agents are most commonly prescribed for Schizophrenia and other illnesses with psychotic symptoms. This article will focus on brief overview of the atypical antipsychotics as a class and brief descriptionRead MoreThe Origins Of Schizophrenia, And Greek And Latin Texts Essay1522 Words   |  7 PagesIntroduction History. Some of the earliest evidence of schizophrenia were seen in the Bible, and Greek and Latin texts. In the Bible, people were accused of being demonically possessed or holy based on the visions they saw (if visions involved Jesus). In Greek mythology, individuals were said to be punished by the Gods of they had symptoms of schizophrenia. Between years 1450-1830 in Europe, and North and South America, people were accused of being witches; similarly, in France, people were thoughtRead MoreMental Illness: The Main Symptoms of Schizophrenia 1546 Words   |  7 Pagesthe stigma behind mental illness. Mental illness ranges anywhere from extremely mild cases to some of the more severe illness such as schizophrenia (Brown, Kaylene; Bradley, Loretta J. 2002). Schizophrenia is a mental illness, which affects one percent of the American population. It is a severe mental illness that affects the brain. For many people schizophrenia is debilitating it is known to prevent an individual from being able to have a normal life (Koch, J. 2010). Hearing voices and havingRead MoreGenetic Risk And Outcome Of Psychosis1636 Words   |  7 Pagesthe first paragraph of the introduction and restated again more specifically in the last paragraph. Many researches have been conducted to understand the etiology of schizophrenia, such as genetic factors or environmental factors thus, I believe the problem is researchable. A brief background of the definition the term schizophrenia is defined in the introduction and much information about the topic is explained throughout the introduction. I believe the article indicates all the variables that wereRead MoreMovie Review: Out of Darkness1576 Words   |  7 Pagescondition of Schizophrenia in the movie, Out of Darkness. The film has a dynamic cast including: Diana Ross as Paulie Cooper (the individual suffering with schizophrenia), Rhonda Stubbins-White as Zoe Price (Paulie’s sister), and Beach Richards as Ms. Cooper (Paulie’s mother). There are a number of other characters portrayed in the film; however for the purpose of this paper, the focus is on these three. The first portion of the paper gives a brief description of the initial onset of Schizophrenia for Paulie;Read MoreSchizophrenia - Informative Speech1514 Words   |  7 PagesSchizophrenia Specific Purpose: To inform my audience about schizophrenia and its consequences. Central Idea: Schizophrenia is a serious mental disorder that affects millions of people and it should not be underestimated or ignored. Introduction I. Does anyone have a friend who hears voices that nobody else hears, sees things that nobody else sees or believes that people are controlling his mind and trying to plot against him? A. Well, I do. B. I have a closeRead MoreEssay about Genetics and Schizophrenia1632 Words   |  7 Pagesdiscuss whether schizophrenia is genetically inherited disorder. There will be an understanding to what schizophrenia is with a brief description in the introduction. This essay will also talk about weather schizophrenia is genetically inherited or weather it is a biological (Inherited) disorder. It will also include weather schizophrenia is cause by other factors such as social factors, environmental, pre natal, childhood and neurobiology. The essay will also state weather schizophrenia is caused by

iOS Development in C# with Xamarin and Visual Studio

In the past, you may have considered Objective-C and iPhone development but the combination of a new architecture and a new programming language together may have been too much. Now with Xamarin Studio, and programming it in C#, you may find the architecture not that bad. You may end up coming back to Objective-C though Xamarin makes feasible any type of iOs programming including games. This is the first of a set of tutorials on programming iOS Apps (ie both iPhone and iPad) and eventually Android Apps in C# using Xamarin Studio. So what is Xamarin Studio? Previously known as MonoTouch Ios and MonoDroid (for Android), the Mac software is Xamarin Studio. This is an IDE that runs on Mac OS X and its pretty good. If youve used MonoDevelop, then youll be on familiar ground. Its not quite as good as Visual Studio in my opinion but thats a matter of taste and cost. Xamarin Studio is great for developing iOS Apps in C# and likely Android, though that depends on your experiences creating those. Xamarin Versions Xamarin Studio comes in four versions: Theres the free one that can create Apps for the App store but those are limited to 32Kb in size which is not a lot! The other three cost starting with the Indie version for $299. On that, you develop on the Mac and can produce Apps of any size. Next is the Business version at $999 and thats the one used for these examples. As well as Xamarin Studio on the Mac it integrates with Visual Studio so you can develop iOS/Android apps as if writing .NET C#. The clever trick is that it uses your Mac to build and debug the App using the iPhone/iPad simulator while you step through code in Visual Studio. The big version is the Enterprise edition but that wont be covered here. In all four cases you need to own a Mac and to deploy Apps in the App store needs you to pay Apple $99 each year. You can manage to offset paying that until you need it, just develop against the iPhone simulator that comes with Xcode. You have to install Xcode but its in the Mac Store and its free. The Business edition does not have a big difference, just that it is on Windows instead of the Mac with free and Indie editions, and it uses the full power of Visual Studio (and Resharper). Part of that comes down to whether you prefer to develop Nibbed or Nibless? Nibbed or Nibless Xamarin integrates into Visual Studio as a plugin that gives new menu options. But it doesnt yet come with a designer like the Xcodes Interface Builder. If you are creating all your views ( the iOS word for controls) at runtime then you can run nibless. A nib (extension .xib) is an XML file that defines the controls etc in views and links events together so when you click on a control, it invokes a method. Xamarin Studio also requires you to use Interface Builder to create nibs but at the time of writing, they have a Visual designer running on the Mac in alpha state. It will likely become available on the PC as well. Xamarin Covers the Whole iOS API The whole iOS API is pretty massive. Apple currently has 1705 documents in the iOS developer library covering all aspects of iOS development. Since they were last reviewed, the quality has improved a lot. Likewise, the iOS API from Xamarin is pretty comprehensive, though you will find yourself referring back to the Apple docs.​ Getting Started After installing Xamarin software on your Mac, create a new Solution. The project choices include iPad, iPhone, and Universal and also with Storyboards. For iPhone, you then have the choice of an Empty Project, Utility Application, Master-Detail Application, Single View application, Tabbed Application or OpenGl Application. You have similar choices for Mac and Android development. Given the lack of designer on Visual Studio, you can take the nibless (Empty Project) route. Its not that difficult but nowhere as easy to get the design looking spot on. In this case, as you are mainly dealing with square buttons, its not a worry. Architecting iOS Forms You are entering into a world described by Views and ViewControllers and these are most important concepts to understand. A ViewController (of which there are several types) controls how data is displayed and manages view and resource management tasks. The actual displaying is done by a View (well a UIView descendant). The User Interface is defined by ViewControllers working together. Well see that in action in tutorial two with a simple nibless App like this one. In the next tutorial, well look in depths at ViewControllers and develop the first complete App.

I Attended Wheaton s Christmas Festival - 830 Words

For this extra credit concert review, I attended Wheaton’s Christmas Festival. I was going anyway and thought I would write a review for it to get some kind of credit. There was a lot performed during this concert and it is not possible to discuss everything in detail so I will discuss the overall atmosphere and some of the specific performances that I particularly enjoyed. The concert started with Claire Holly singing Once in a Royal David’s City composed by Henry J. Gauntlett in 1849 (Hawn and Hanna). It was a solo performance and it was peaceful. The Symphonic Band then played and this was followed by everyone, including the audience, singing Come thou Long Expected Jesus composed by Charles Wesley in 1744 (Carrol). Next, which I will discuss in more detail, Wolcum Yole composed by Benjamin Britten in 1942 (Wolcum Yole!). This was interesting to listen to because we have spoken about Benjamin Britten in class. This piece was mainly monophonic and contained a lot of a gitated style. It was not smooth; it was all over the place. This is a much more modern song as one can tell. It strays away from the much more conservative-style pieces that Giovanni Artusi was an advocate for in the sixteenth and seventeenth centuries. Several more songs were played and sung by the Concert Choir, Women’s Chorale and the Percussion Ensemble which were followed by my favorite piece in the concert, Fum Fum Fum which was thought to be composed in the sixteen or seventeenth centuries but was notShow MoreRelated_x000C_Introduction to Statistics and Data Analysis355457 Words   |  1422 PagesMacintosh are registered trademarks of Apple Computer, Inc. Used herein under license. Library of Congress Control Number: 2006933904 Student Edition: ISBN-13: 978-0-495-11873-2 ISBN-10: 0-495-11873-7 ââ€"   To my nephews, Jesse and Luke Smidt, who bet I wouldn’t put their names in this book. R. P. ââ€"   To my wife, Sally, and my daughter, Anna C. O. ââ€"   To Carol, Allie, and Teri. J. D. ââ€"   About the Authors puter Teacher of the Year award in 1988 and received the Siemens Award for Advanced

An Idea That Protects A Proprietor s Land Title - 1742 Words

Indefeasibility Introduction Indefeasibility of title is an idea that protects a proprietor’s land title. It allows for the proprietor to be immune from attack by adverse claims and interests in the land, in which he, the proprietor, is registered. This concept is based around the Torrens system in New Zealand, this concept consists of three main principles, the mirror, the curtain and the insurance principles. This essay will discuss the concept of indefeasibility of title, the Torrens system and how these have provided security of title for land owners in New Zealand. I will also report on two significant cases that will illustrate the concept of Indefeasibility of title, they are Frazer v Walker and Efstratiou, Glantschnig and Petrovic v Glatnschnig. Common Law Common law was implemented in New Zealand when the British settlers arrived. It was in accordance with English law and was known as the Deeds system and Act and was replaced by the Torrens system in 1870. Common Law basically stated that no one could confer a better title than the one they have and therefore if a deed was deemed invalid, so too was the title (Hinde 2013). Torrens System The Torrens system is what indefeasibility of title has been built around. It has existed since 1870 and has been refined and is now found in the Land Transfer Act 1952. The system, as mentioned earlier, consists of three principles, the mirror principle, the curtain principle and the insurance principle. †¢ The Mirror principle:Show MoreRelatedThe Objectives Of The Lra 2002 Replaces And Repeals The Land Registration Act 19251432 Words   |  6 Pagesreplaces and repeals the Land Registration Act 1925 in its entirety. However, the same principle which also applied in 2002 Act. Law based on these three principles. The â€Å"Mirror principle† provide that by the register should reflect or reflect all the rights and interests of the registered land titles. The curtain principle which is purchasers need look no further than the register and are not concerned with trusts. The â€Å"Insurance Principles† is a simple, if the title is officially registeredRead MoreCase Analysis : Business Partnership1433 Words   |  6 PagesWhile many companies are formed by investors, best friends, or family members it is always a good idea to register the company and make it a legal partnership. Partnership agreements serve several purposes, but mostly it will benefit all parties inv olved. In this scenario, assuming Chad wants equal decision making rights but not the liability of the company’s debt LLP is a good option to register the company under, also assuming that Dad wants the same for his son Chad. For instance, â€Å"In a limitedRead More Revolution Essay2438 Words   |  10 Pagesfrom 1764-1766. Britain’s national debt had soared to 133 million pounds due to the war. Grenville decided to propose several taxes on the American colonists, including the Stamp Act. The Stamp Act required embossed markings on court documents, land titles, contracts, playing cards, newspapers, and basically anything printed. Grenville figured that the tax would cover part of the national debt and the cost for keeping ten thousand soldiers in America—roughly 200,000 pounds per year. The ColonistsRead MoreThe Effect of the Wapping Revolution on British Journalism Essay1818 Words   |  8 PagesThe Effect of the Wapping Revolution on British Journalism In 1986, when Rupert Murdoch, the owner of News International, moved production of his major titles (The Times, The Sunday Times, The Sun and The News of the World) from Fleet Street to Wapping, he set about an irreversible chain reaction in the structure of journalism in the UK. Although I believe that some kind of major political and technological change in the press was inevitable and arguably overdue byRead More‘Charles’ Ability to Finance His Government Effectively and Without Too Much Resentment During the Personal Rule Was a Remarkable Achievement.’2100 Words   |  9 Pages‘Charles’ ability to finance his government effectively and without too much resentment during the personal rule was a remarkable achievement.’ How Far Do You Agree? For the greater part of the 1630’s Englishmen paid their taxes, most likely grumbling whilst doing it, but they were paid. During his personal rule 1629-40, Charles I needed to raise revenue by using non-parliamentary means, i.e. in ways he would not need a parliament’s permission to collect. In order to do this, Charles changedRead MoreRace And Ethnicity From An Anglo American War Of 1846 And The United States3084 Words   |  13 PagesIn the span of 50 years a lot can change especially when a power struggle began brewing between land hungry President James Polk of the United States and recently independent Mexico. California began its transition from the dominance of Spanish powered Missions to independent Ranchos. In Two Years Before the Mast Richard Henry Dana Jr explores the issue of race and ethnicity from an Anglo perspective in newly opened for trade to foreigners California. From the PBS website, one is able to learn aboutRead MoreForms of Commercial Organizat ion12473 Words   |  50 PagesA Business Organization which is owned and managed by a single person with or without the help of family members is called as sole trader or sole proprietor. The sole trading concern is run on the principle â€Å"All is he and he is all in all†. 1.1 Features 1. One-man Ownership and Control A sole trading concern is owned by an individual. The proprietor is the sole owner and master of the business. He independently manages and controls the business without the interference of any other person. 2.Read MoreEssay on Edgar Allan Poe2364 Words   |  10 Pages Edgar Allan Poe nbsp;nbsp;nbsp;nbsp;nbsp;Ralph Waldo Emerson called him the jingle man, Mark Twain said that his prose was unreadable, and Henry James felt that a taste for his work was the mark of a second-rate sensibility. According to T. S. Eliot, quot;the forms which his lively curiosity takes are those in which a preadolescent mentality delights.quot; After notices like those, most reputations would be sunk without a trace, and yet Edgar Allan Poe shows no sign whatsoever of looseningRead MoreMedia Law: Defamation, Copyright, Etc23627 Words   |  95 Pagesdocuments such as pleadings and proofs of evidence: This will not protect media reports of the contents of these documents. A fair and accurate report by newspaper, radio or television of proceedings publicly heard before any Court exercising judicial authority shall, if published contemporaneously with such proceedings, be privileged (provided no blasphemous or indecent matter is included) - Section 6 Wrongs Act. This section protects reports of proceedings heard before a Court exercising judicialRead MoreMedia Law: Defamation, Copyright, Etc23639 Words   |  95 Pagesdocuments such as pleadings and proofs of evidence: This will not protect media reports of the contents of these documents. A fair and accurate report by newspaper, radio or television of proceedings publicly heard before any Court exercising judicial authority shall, if published contemporaneously with such proceedings, be privileged (provided no blasphemous or indecent matter is included) - Section 6 Wrongs Act. This section protects reports of proceedings heard before a Court exercising judicial

Exploring Modernism In Architecture Architecture Essay Free Essays

string(254) " which was developed by Dr Jonas Salk, the developer of infantile paralysis vaccinum had intended for a research lab which was non merely someplace for biological research, but a topographic point which you could ‘invite a adult male like Picasso\." For my essay on Modernism in architecture I intend to research an designer of the modernist period in order to set up the signifier, doctrine and societal thoughts behind modernism. ‘The term modern architecture is equivocal. It can be understood to mention to all edifices of the modern period regardless of their ideological footing, or it can be understood more specifically as an architecture conscious of its ain modernness and nisus for alteration. We will write a custom essay sample on Exploring Modernism In Architecture Architecture Essay or any similar topic only for you Order Now ‘ Modern architecture is a class which normally complements edifices of the twentieth and twenty-first century. It would include Bauhaus / International manners ( sometimes used to depict Bauhaus architecture in United States ) and besides brutalism. Modernism was a reaction against eclectic method and the munificent stylistic surpluss of the Art Deco, Art Nouveau and the Victorian ages. However, it is still a affair of gustatory sensation. Even though Bauhaus, a German design school 3 ( Operated from 1919-33 By laminitis Walter Gropius, so by Hans Mayer and Ludwig Mies der Van Rohe ) which had deeply influenced humanistic disciplines and architecture had been more concerned with societal facets of design ; none the lupus erythematosus, International manner shortly became a symbolism of Capitalism. Fig.2 shows an interesting and most celebrated illustration of this International manner. This manner of architecture was reserved chiefly for office blocks, but was besides seen in places built for the rich and celebrated. Fig.2 shows another edifice widely known for its ‘functionalist aesthetic and a chef-d’oeuvre of corporate modernism. ‘4 5 There were many designers who attached their name to this modernistic epoch, some of the best known being Frank Lloyd Wright ( fig.6 ) , Walter Gropius ( fig.5 ) , Le Corbusier ( fig.2 ) and Ludwig Mies der Van Rohe ( fig.3 ) . 6Fig.6 shows Falling H2O which was a genuinely iconic edifice for many. Willard huntington wrights design which was for a residential place was above a waterfall. This edifice portrayed his position of organic architecture. Modern architecture was found to be disputing traditional instructions which were thought to be suited for architectural design and construction. Modernist ‘s interior decorators went on to reason that designers should plan everything which is necessary for society. From every item and furniture in the inside and outsides of edifices and even led to designers planing the most low of edifices. I have looked at the broader definition of modernism along with the innovators who drove this manner. Louis Kahn is the designer I have chosen to analyze in deepness. His positions of modernism are good known through the modern universe of architecture. Louis Kahn 7 Itze-Leib Schmuilowsky ( February 20, 1901 or 1902 – March 17, 1974 ) , or more normally known in the universe of architecture as Louis Kahn was an designer who was infused within the International manner. Kahn graduated from the University Of Pennsylvania School Of Fine Arts in 1924. In the late 1930 ‘s Kahn ‘s was working as a adviser to the Philadelphia Housing Authority. His association with modern architecture grew as he worked with Europeans Stonorov and George Howe with whom Kahn designed many wartime lodging undertakings which can be seen in fig.8. From these experiences it gave Kahn a sense of societal duty which was subsequently reflected in his doctrine. 1947 was a twelvemonth where the Kahn started to emerge. His calling had established to a point where he had started a learning calling at Yale University as the Chief Critic in Architectural Design and Professor of Architecture, until 1957. Then at the University of Pennsylvania as Cret Professor of Arc hitecture until his decease lonely decease in a work forces ‘s room lavatory in Pennsylvania Station in New York. Kahn died in deep debt despite his flush calling. 8 Louis Kahn was a review of mainstream modernism ; his work represented the New Monumentality motion which was besides promoted by Siegfried Gieldion, Josep Llios Sert and Kahn ‘s wise man George Howe. Kahn ‘s edifices are improbably precise in their building of topographic points for people. I found some pieces of Kahn ‘s work peculiarly interesting to analyze from a modernistic architectural position. From the list of his most of import plants I have selected a few which I believe to be peculiarly symbolic to this essay. From more than a twelve houses which had been designed by Kahn Esherick House was the most celebrated. I found Esherick house to one of his most fantastic pieces of work which shows us the way which he subsequently followed in. A critique say ‘s: 11 9 ‘aˆÂ ¦The Esherick House is decidedly one of Kahn ‘s most of import plants which defined lessons he ‘d travel on to utilize in ulterior undertakings. ‘ 12 10 By this I believe he means that Kahn was happening his component which he had so travel onto usage in ulterior undertakings. Kahn ‘s calling comprises of a batch of interesting work, nevertheless, Esherick house stands as one of his most of import pieces of work. In the devising of the house the control of visible radiation had been the preoccupation since the start, and he genuinely had achieved harmoniousness through natural visible radiation every bit good as distinguishable manner through the transcendency and geometric item. Kahn ‘s rules of visible radiation, materiality and geometry are clearly seeable here. He starts to enforce his future positions of signifier in elusive features of this house. At a glimpse it is merely concrete and wood which combine to make the frontages and interior infinites. The house features a textured howitzer coating, with keyhole window which are framed with natural Apilong wood placed at irregular intervals on the forepart facade. The floor program is a refined design by Kahn. It is shown to incorporate two symmetrical rectangles which allow structural support and openness. This truly modernistic construction shows how Kahn ‘s work would blossom in ulterior old ages. The Esherick house ‘s pure usage of geometry and abstract signifier reflect his modernistic attack to architecture. Kahns work is much greater dipected in his later and much larger undertakings. The Salk Laboratories which was developed by Dr Jonas Salk, the developer of infantile paralysis vaccinum had intended for a research lab which was non merely someplace for biological research, but a topographic point which you could ‘invite a adult male like Picasso. You read "Exploring Modernism In Architecture Architecture Essay" in category "Essay examples" ’13 The stuffs used for this huge undertaking were concrete, wood, marble and he besides used the component of H2O in his design which as the monolithic composite was juxtaposed against the Pacific Ocean was suiting. I found a really fitting description of The Salk research labs: Kahn ‘s usage of order before signifier shows us how he depicted a edifice to be like a perfect being with complexness of usage inside every bit good as on the outside. I found a really interesting quotation mark from Kahn about the Salk laboratories. His doctrine of design shows use the sort of adult male he was and purposes he perused: â€Å" I did non follow the dictates of the scientists, who said that they are so dedicated to what they are making that when lunch period comes all they do is clear off the trial tubing from the benches and eat their tiffin on these benches. I asked them: was it non a strain with all these noises? And they answered: the noises of the iceboxs are awful ; the noises of extractors are awful ; the trickling of the H2O is awful. Everything was awful including the noises of the air-conditioning system. So I would non listen to them as to what should be done. And I realised that there should be a clean air and chromium steel steel country, and a carpet and oak table country. From this realization signifier became. I separated the surveies from the research lab and placed them over gardens. The garden became out-of-door infinites where one can speak. Now one demand non pass all the clip in the research labs. When one knows what to make, there is merely small clip one needs for making it. It is merely when 1 does non cognize what to make that it takes so much clip. And to cognize what to make is the secret of it all. † I deduce from this extract Kahn ‘s cognition and assurance. I see how Kahn believed in a new modern signifier of architecture. He says it as if he already has the ideas and thoughts to transform edifices into styled and ordered infinite. Kahn ‘s readings were apparently much clearer ; he wanted a modern architecture less concerned with aesthetics and what the edifice looks like. He was more intrigued by the infinites of the edifice and how the infinites were being used, and what order this would make for them. He wanted to do infinites which would impact the experiences of those who inhabited those infinites. Salk research lab shows us a design which had preponderantly established the foundational significance ; order of infinite an so the geometries. He used this construction of idea for his designs of all establishments such as Salk laboratories. ‘The concluding version of the Salk research labs brought him to accept a solution in which services were as ‘repressed ‘ or concealed as in any office edifice by Mies Van der Rohe ‘ From this big undertaking he moved onto a following, nevertheless, this one staying unbuilt whilst he was still populating. Jatiyo Sangshad Bhaban in Dhaka, Bangladesh is regarded to be on this is great memorials of international modernism. This edifice was considered as his chef-d’oeuvre of his life-time. Construction of this edifice had stated by 1961 nevertheless due to its huge outrageousness did n’t complete building until nine old ages after his decease in 1983 which means it took around 20 old ages to construct. The national assembly edifice was Kahn ‘s most of import piece of work. The infinite was really expansive. The interior country for the Assembly edifice was spilt into 3 subdivisions. The zone in the Centre provides circulation. The chief country or cardinal zone is for the chief assembly. The exterior zone is where the offices and sofas are, besides this is where the entryway to the chief mosque is. In the design we can see how natural visible radiation is a really of import component in this edifice. The edifice seems as if it is entirely for spiritual intents and has a heavy religious genius. â€Å" In the assembly I have introduced a light-giving component to the inside of the program. If you see a series of columns you can state that the pick of columns is a pick in visible radiation. The columns as solids frame the infinites of light. Now think of it merely in contrary and believe that the columns are hollow and much bigger and that their walls can themselves give visible radiation, so the nothingnesss are suites, and the column is the shaper of visible radiation and can take on complex forms and be the protagonist of infinites and give visible radiation to infinites. I am working to develop the component to such an extent that it becomes a poetic entity which has its ain beauty outside of its topographic point in the composing. In this manner it becomes correspondent to the solid column I mentioned supra as a giver of visible radiation. † Here Kahn negotiations about the Bangladesh undertaking. He reiterates the importance of visible radiation in the infinite and his poetic entity which he adds to every design to make a great sense of beauty. In the designing of these three undertakings we can see how Kahn has used his cognition to assist make infinites which execute both signifier and map desirably to the client. Kahn negotiations about how his greater apprehension of what is needed helps him finish his undertaking easy. Kahn negotiations approximately beauty as the great philosopher St Thomas Aquinas did. Aquinas believed that beauty consisted of four ingredients: Integrity, integrity, symmetricalness, and glow. By unity he meant that something is complete on its ain without any being dependent on anything outside it. By integrity he means every portion has a ground and ca n’t be taken off without destructing the whole beauty of it. Symmetry mentioning to equilibrate, something ca n’t merely alter without a corresponding consequence. This was similar the invariables which had appeared in Kahn ‘s work. The sense of composing, the unity of a edifice fear for stuff, sense of ‘room ‘ , light as the shaper of the construction and architecture of connexion Kahn tried to use these theoretical accounts into all of his undertakings. One even described him as: â€Å" a philosopher among designers † . This is from his every showing doctrine on his work. Basically Kahn saw architecture as being a religious signifier of communicating. He grew a strong relation with each undertaking by using a strong hierarchy with order being the most of import. Kahn was celebrated for being a review of modernism. He found many influential designers of the clip to hold been misjudging the order of their designs. Kahns critue started with him rejecting a ‘free program ‘ ; a construct which Mies new wave der Rohe and Le Corbusier had attached themselves to, along with modernism. Kahn believed that dividing these two constructs of signifier from the construction, would intend the free program as antecedently interpreted by Van de Rohe and Le Corbusier had ‘ opened up a nothingness that could merely be filled with subjective intuition. ‘ Basically Kahn ‘s work did look consistent with that of the broader position of architecture nevertheless, his position of modern architecture was something which was unpredictable and had no regulations to follow or rules to ad ear to. He found that the international manner of modern architecture at the clip which was being used by many designers in America and Europe had been excessively concerned with the signifier and non the map. ‘Kahn was concerned with the things adult male has been looking for since the beginning – and in this he was a fundamentalist – was non interested in the realisation, of something which had already occurred, but in the possibility that something will happen within the wallsaˆÂ ¦ ‘ This tells us that Kahn was more of Prophet than merely a sermonizer. He wanted to alter the positions on architecture and present what he believed to be the necessary status for the presence of architecture. ‘Mies ‘s sensitivites react to imposed structural order with small inspiration, Le Corbusier passes through order impatiently and hastes to organize. ‘ Kahn talked about Mies Van der Rohe and Le Corbusier imperfectness in structural order, and their haste of order leads to an imperfectness in signifier. Kahns order derived from nature and this is reflected in his undertakings. ‘In the nature of infinite is the spirit and the will to be in a certain manner. Design must closely follow that will. ‘ The pure order, signifier and geometry is why Louis Kahn still act upon the universe today. His work straight impacts and inspires signifiers of architecture today such as station modernism and neo positivist. More than this Louis Kahn redefined modernism. He has thrilled looker-ons with his huge doctrine ; nevertheless his frequenters merely appeared in his ulterior old ages. Kahn adapted architecture and had an input as to what we see when we analyse today. He showed us in his huge texts, to every item the visions he had, and how he intended to raise these visions. Predominately we can see that he was floating off from modernism, nevertheless, I have studied how Kahn ‘s vision set modernism into path someplace that it would n’t hold been without his influence. â€Å" It was non belief, non design, non pattern, but the kernel from which an establishment could emerge†¦ † How to cite Exploring Modernism In Architecture Architecture Essay, Essay examples

Intimate Relationship and Communication Sample Essay Example For Students

Intimate Relationship and Communication Sample Essay Self-concept and Self Esteem* To hold successful relationships. we must first accept and experience good about ourselves. * A positive self-concept and a healthy degree or self-esteem aid us love and esteem others. * As grownups. we likely have a sense that we’re fundamentally loveable. worthwhile people and that we can swear others is. as babes and kids. we felt loved. valued and respected ; if grownups responded to our demands in a moderately appropriate manner ; and if they gave us the freedom to research and develop a sense of being separate persons. * Harmonizing to psychologist Erik Erikson. it continues to develop as we encounter and resolve assorted crises at each phase of life. * Gender function – the activities. abilities. and features our civilization deems appropriate for us based on whether we’re male or female. * Our grownup manners of loving may be based on the manners of fond regard we established in babyhood with our female parent. male parent or other primary health professional. Peoples who are secure in their intimate relationships likely had a secure. swearing. common fulfilling fond regard to their female parent. male parent or other parenting figure. * People’s earliest experiences and relationships were less than ideal. nevertheless. they can still set up fulfilling relationships in maturity. Peoples can be resilient and flexible. They have the capacity to alter their thoughts. beliefs and behaviour forms. They can larn ways to raise their self-esteem ; they can go more trustful. accepting. and appreciative of others. Friendship* Friendships spring people the chance to portion themselves and detect others. * The friendly relationships we form in childhood are of import in our development ; through them we learn about tolerance. sharing and trust. * Companionship – Friends are relaxed and happy in each other’s company. They typically have common values and involvements and do programs to pass clip together. * Respect – Friends have a basic regard for each other’s humanity and individualism. Good friends respect each other’s feelings and sentiments and work to decide their differences without take downing or contemptuous each other. There are besides honorable with each other. * Acceptance – Friends feel free to be themselves and show their feelings without fright of ridicule or unfavorable judgment. * Help – Sharing clip. energy and even material goods is of import to friendship. Friends know they can trust on each other in times of demand. * Trust – Friends are secure in the cognition that they will non deliberately hurt each other. * Loyalty – Friends can number on each other. They stand up for each other in both word and title. * Mutuality – Friends retain their single individualities. but close friendly relationships are characterized by a sense of mutualness – â€Å"what affects you affects me. † Friends portion the ups and downs in each other’s lives. * Reciprocity – Friendships are mutual. There is discussion between friends and the feeling that both portion joys and burdens more or less every bit over clip. * Friendships are normally considered both stabler and longer enduring than intimate partnership. Friends are frequently more accepting and less critical than lovers. likely because their outlooks are different. Love. Sexual activity and Familiarity * Love encompasses antonyms: fondness and choler. exhilaration and ennui. stableness and alteration. bonds and freedom. * Love does non give us perfect felicity. but it does give our lives intending. * Love reflects the positive factors that draw people together and prolong them in relationship. * Sex brings exhilaration and passion to the relationship. * It intensifies the relationship and adds captivation and pleasance. * The finding to go on. reflects the stable factors that help keep the relationship. Sternberg’s Love Triangle Uncle Dan EssayGender and Communication* Men tend to utilize conversation in a competitory manner. possibly trusting to set up laterality in relationships. * Women tend to utilize conversation in a more affiliative manner. possibly trusting to set up friendly relationship. * Men tend to speak more – though without unwraping more – and listen less. Womans tend to utilize good listening accomplishments such as oculus contact. frequent nodding. focussed attending. and inquiring relevant inquiries. Conflict and Conflict Resolution* Clarify the issue – Take duty for believing through your feelings and detecting what’s truly trouble oneselfing you. Agree that one spouse will talk first and have the opportunity to talk to the full while the other listens. Then change by reversal the function. Agree to speak merely about the subject at manus and non acquire distracted by other issues. * Find out what each individual wants – inquire your spouse to show his or her desires. Don’t presume what your spouse wants to talk for him or her. * Identify assorted options for acquiring each individual what he or she wants – pattern brainstorming to bring forth a assortment of options. * Decide how to negociate – work out some understandings or programs for alteration. * Solidify the understandings – travel over the program verbally and compose it down. if necessary ; to guarantee that you both understand and agree to it. * Review and renegociate à ¢â‚¬â€œ make up ones mind on a clip frame for seeking out the new program. and put a clip to discourse how it’s working. Make accommodation as needed.

Selected Aspect Of The Microbreweries Boom â€Myassignmenthelp.Com

Question: Discuss About The Selected Aspect Of The Microbreweries Boom? Answer: Introducation The machines Easy Brew will make crafting of beer delightful for customers at the comfort of their home with latest technology. Customers can brew beer with products of the company using in-built recipes as well as recipes and natural ingredients for brewing will be delivered at doorstep by Easy Brew community. The machine will be targeted to the university students and young population of New South Wales. The machine is planned to be distributed from Sydney to Wollongong and Newcastle and other parts of New South Wales. The sales of the machines is expected to increase by 15% every year so that revenue of 1.2 million AUD can be obtained by third year of operation. The fine quality of products will delight customers of New South Wales as they can brew beers at home after just one-time investment in purchasing machines of Easy Brew.(Schaper et al 2014). Marketing The Company aims to gain customers for repeat purchase by delivering quality products to customers. The product will focus on excellent taste of beer which will attract loyal customer base. The company will promote itself as a Youth Brand and will aim to position itself as a brand with excitement personality. The company will make use of both Above the Line and Below the Line promotional activities for promoting the product. The products will be promoted in industry show of liquor, fairs and will target campus university students and youths. Online promotional strategy on digital platforms will also be used to gain a good customer base (McKeever 2016). The organization which manufactures Easy Brew will have separate divisions for the, bottling and shipping process, production and delivery process. The manufacturing of products will follow high quality standards and products will be equipped modern technology. The Easy Brew machine will be available to customers online and can be ordered by mobile apps for home delivery in Sydney. The company will deliver Easy Brew machine based on Just-In-time technology for premium products. The company will make payment easy and safe for customers online by building a safe digital platform (Gnauck, Hart and Pagel 2014) Initial investment of 150,000 AUD will be required by Easy Brew to begin its operation. The manufacturing will start with loans from banks, investment from friends and family and will fund itself by angel investors and venture capitalists for expanding its operation in New South Wales. The price of EasyBrew machines will be reduced by 12% for first 6 months so that the Company break evens and becomes profitable. After two years, 20 % bottom-line profitability is expected. The machines of Easy Brew are expected to achieve increase 15 % sales year on year so that revenue at the end of third year can be expected to be 1.2 million AUD. 1.1 MISSION STATEMENT- To delight customers by delivering them high-quality beer machines which will make the brewing process delightful for them at comfort of home. The company which manufactures Easy Brew started its operation in Sydney, New South Wales. Within 2 years of operation the Easy Brew machines have gained popularity among customers of Sydney. Distribution of Easy Brew has been planned for expansion so that the products can be available in all markets of New South Wales. The company has 20 people in sales, delivery and production. The Easy Brew machines make crafting of beer at home easier by modern technology , customers can select their recipes from RFID tags of machine, some machines of EasyBrew are automated and in the premium range to make crafting of beer delightful at comfort of home for customers(Watne and Hakala 2013). The business goals of Easy Brew are as follows- 1)To achieve a growth of sales revenue to 1.2 million AUD by the third year of its operation. 2) To distribute products through online platform like company website, through websites like Direct Shop and mobile apps. 3) To expand its distribution in popular cities of Australia like Sydney, Wollongong and Newcastle within next five years. 4) To deliver products of high quality to customers and to remove any obstacle between the product and customer by delivering them high quality products which can make the brewing process easy and delightful so that customers make repeat purchase. 5) To promote the products on digital platforms by making customers aware about easy brewing at home and by building customer relationships using digital tools like data mining and e-mail marketing and make home delivery available for customers (Leschke 2013). Regional producers have dominated the beer market in New South Wales and Sydney. The company faces indirect competition from ready- made beer brands like Malt Shovel Brewery which is a part of Lion, St Arnou, Stockade Brew Co and Pines Brewing Company. Regional beer companies in Sydney and New South Wales have to compete with brands like Lion, Carlton and United Breweries and Coopers Brewery. It is difficult for Easy Brew products to promote the new concept of brewing beer at home. New South Wales has 7.7 million populations which is almost one third of Australias population. More than 5 million people live in Sydney and Wollongong and Newcastle have three fourth of population of NSW. The state has popular universities like University of Sydney, University of New Castle and University of New South Wales and there are 35% sales of beer in among college campus communities. Population in the state grows because of immigration and industry growth which can add to customer base of Easy Brew(Argent 2017). Product And Target Market The machine Easy Brew will make the craft of brewing easy for customers. The machines will be equipped with computerized program for customers to create recipes of their own. Fresh grains, yeast and hops will be delivered to customers along with machines of Easy brew. Around 6 litres of beer can be manufactured within 2 hours using Easy Brew products. Easy Brew will have fully automated machine called Easy Brew Pro which will be priced in premium range. Thecompany targets two sets of customers in Sydney and New South Wales-customers who study in Universities and young men and women in the age bracket of 25-30 living in the cities by making the product available in popular pubs and local markets(Hollensen 2015). The producers of Easy Brew must obtain license to distribute its products to customers. Standard hours for trading will be applied to the license and the license can be applied as an individual or corporation. Consent of Local Council will be required and if the applicant of license is an individual, Certificate of Responsible Service of Alcohol must be provided. Ogranizational Structure And Staffing The organization structure of manufacturer of Easy Brew product will be flexible with less hierarchy and there will be managers for the manufacturing, shipping operations, digital marketing and sales division. The company will follow a Just-in-time technology for shipping of beer machines. An open communication will be followed throughout the organization and all departments will collaborate with each other for a smooth flow of information. (Russell-Jones 2014). Equipment Required Equipment required for manufacturing the products of Easy Brew will be gallon pot, airlock, stopper, hydrometer jar , nylon bags(Thomas 2013). The production process will follow the Just-in-Time technology for certain premium products of Easy brew for assembling of product parts.The production process will enable customers to manufacture beer using latest technology. The premium products will be fully automated. Customers can select recipes from RFID tags of machines of Easy Brew. The products will brew beers with home delivered natural ingredients which will give the crafted beer its unique color and taste(Maier 2013). References Argent, N., 2017. Heading down to the local? Australian rural development and the evolving spatiality of the craft beer sector.Journal of Rural Studies. Gnauck, B., Hart, C. and Pagel, L., 2014. Blackrocks: Craft Brewing-From Hobby To Business: Applying Strategic Management To The Small Firm.Journal of Business Case Studies (Online),10(2), p.103. Hollensen, S., 2015.Marketing management: A relationship approach. Pearson Education.a Leschke, J., 2013. Business model mapping: A new tool to encourage entrepreneurial activity and accelerate new venture creation.Journal of Marketing Development and Competitiveness,7(1), pp.18-26. Maier, T., 2013.Selected aspect of the microbreweries boom.Agris on-line Papers in Economics and Informatics,5(4), p.135. McKeever, M., 2016.How to write a business plan.Nolo. Russell-Jones, N., 2014.Business Planning Pocketbook.Management Pocketbooks. Schaper, M.T., Volery, T., Weber, P.C. and Gibson, B., 2014.Entrepreneurship and small business. Thomas, D., 2013. Malting: the latest craft.Brewer Distiller Int., London, UK. Watne, T.A. and Hakala, H., 2013. Inventor, founder or developer?An enquiry into the passion that drives craft breweries in Victoria, Australia.Journal of Marketing Development and Competitiveness,7(3), p.54.

Huntington’s Disease Samples for Students †MyAssignmenthelp.com

Question: Discuss about the Huntingtons Disease. Answer: Huntingtons Disease Huntingtons disease (HD) is a dominantly inherited neurogenerative disorder resulting from the unstable expansion of the CAG trinucleotide in the HTT gene (Raymond, et al., 2011). The HTT gene serves as an instruction template for the protein huntingtin. The exact function of huntingtin is, however, unknown but it is proposed to play a role foetal development before birth, and also has a role in nerve cells (NIH, 2015). HD is a progressive disorder characterised by unwanted choreatic movements. Pathophysiology The expanded CAG repeat produces an extended polyglutamine tail on the huntingtin protein, and this causes the protein to cleavage and also generate toxic fragments (Jankovic Ashizawa, 2008). The polyglutamine content in the toxic fragments prompts cross-linking, and this forms aggregates that are resistant to degradation, and also causes interference with various normal cellular functions, predominantly mitochondrial energy metabolism, disrupted calcium signalling, abnormal protein interactions, transcriptional dysregulation of a variety of genes, alterations in axonal transportation of critical factors, autophagy, and altered proteasomal functioning (Zuccato, et al., 2010; Johnson Davidson, 2010). A reduction in the level of wild-type huntingtin has not shown to be contributing to the disease, it, however, magnifies the adverse effects of the generated fragments. The disease primarily affects the striatum, and the clinical presentation is primarily as a result of the damage (mainly cell loss and gliosis), include behaviour changes, cognitive impairment, and loss of coordination (Jankovic Ashizawa, 2008). Additionally, further pathological changes are also evidenced in several other cortical and sub-cortical structures (Rosas, et al., 2008). The hallmark feature of Huntingtons disease (chorea), results from striatal dysfunction. This pathological process is the most accepted and as a result, therapeutic interventions are being designed to improve mitochondrial function, facilitate retardation of apoptosis, enhance autophagic consumption of mutant proteins, block the cleavage of huntingtin at the sites that produce the toxic fragments, and also improve cell-cell interactions (Hannan, 2005). Existing treatments Drug therapy Neuroleptics such as haloperidol (typical) and olanzapine (atypical), benzodiazepines the monoamine-depleting agent tetrabenazine are used to suppress choreic movements (Huntington Study Group, 2006). While psychiatric disturbances that include depression are managed using psychotropic and antiepileptic agents (Frank, 2014) However, pharmacological treatment is only limited to the treatment of signs and symptoms and cannot change the disease development or progression (Killoran Biglan, 2014). Further, chorea may be exacerbated by L-dopa containing compounds (Warby, et al., 2014) Non-medication interventions Persons suffering from Huntingtons disease require psychotherapy from a psychotherapist to help in the management of behavioural problems, help the patient in developing coping strategies, and also manage the patients expectations through the disease progression. Speech therapy and physical therapy may also be indicated because HD can impair the control of muscles. A speech therapist will help the patient improve their ability to speak clearly, or in the use of communication devices. Physical therapy will help the patient enhance coordination, balance, flexibility, and strength. Persons with HD also require supportive care with special attention to nursing, diet, special equipment, emotional support, counselling, practical help and relief in forms such as state and federal benefits (Williams, et al., 2009). The primary inadequacy of non-pharmacological treatment is that it cannot be used as the primary treatment in the treatment of HD, but rather as secondary. Surgical treatment Surgical treatment plays a minimal role in HD. Surgical interventions are basically in the experimental phase and they include ablative surgery and cell transplantation (Demeestere Vandenberghe, 2010). These interventions show some promise but their efficacy has not been fully demonstrated. The primary advantage of surgical interventions is the possibility that they can modify the course of the disease. On the other hand, the primary disadvantage is that these procedures are that for the treatment of a widespread disease such as Huntingtons disease, the effects of the surgery tend to be confined to the local region where it is performed (Demeestere Vandenberghe, 2010). The impact on the individual health system of the disease and treatment Research on the economic cost of HD has not been well studied. There are only two notable studies on the same, one being conducted in the US (Divino, et al., 2013), and another in Europe (Busse, et al., 2011). The authors also claim that the primary cost in HD is the primary healthcare component. From the two studies, it is evident that the direct economic burden of the condition is substantial and it increases as the disease progresses. In 2013, the estimated cost for the treatment of an HD patient was $4,947 in the early HD stage, and this rises to $22,582 in the late stage, whereas in the UK, the earliest stages cost approximately 2250 per person and 89 760 in the later stages (Jones, et al., 2016). Other than the direct economic cost, HD has a significant impact on both the individual and their family. The onset of the diseases signs and symptoms is 35-45 years (Vamos, et al., 2007). This is the period when the family-life cycle is most complex, as characterised by childbearing and rearing and career development. The family suffers a great deal of distress and grief in the sense that they have to mourn those who have passed on and anticipated further losses for those who will die. Overall burden of disease It is estimated that 5 to 7 persons per 100,000 are affected by HD in the Western Countries (Australian Huntington's Disease Association, 2017). This is however not in the case as some regions of Western Europe have no HD whereas the concentration is quite high in others as evidenced in Lake Maracaibo in Venezuela where the prevalence is approximately 700 per 100,000 (Australian Huntington's Disease Association, 2017). As per the Australian Huntington's Disease Association, in Australia, approximately 1,800 people have the condition whereas another 9,000 are at risk. Its prevalence in Australia has been evidenced to increase at 15-20% per decade (Rawlins, et al., 2016). In the UK, it is estimated that 12 out of every 1000, 000 people are affected (Evans, et al., 2013), whereas in the US, 7 out of every 100,000 persons are at risk of developing the condition (Rawlins, et al., 2016). According to Rawlins et al., the lowest rates of HD are seen among Asians. References Australian Huntington's Disease Association, 2017. How Common Is Huntington's Disease (HD)?. [Online] Available at: https://www.huntingtonsnsw.org.au/information/hd-facts/how-common[Accessed 18 September 2017]. Busse, M. et al., 2011. Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study.. PLoS Curr. , 21(3), p. RRN1206. Demeestere, J. Vandenberghe, W., 2010. Experimental Surgical Therapies for Huntingtons Disease. CNS Neuroscience and Therapeutics, 17(6), pp. 705-713. Divino, V. et al., 2013. The direct medical costs of Huntington's disease by stage. A retrospective commercial and Medicaid claims data analysis.. J Med Econ., 16(8), pp. 1043-50. Evans, S. et al., 2013. Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records.. J Neurol Neurosurg Psychiatry, 84(10), pp. 1156-60. Frank, S., 2014. Treatment of Huntingtons Disease. Neurotherapeutics, 11(1), pp. 153-160. Hannan, A. J., 2005. Novel therapeutic targets for Huntington's disease.. Expert Opin Ther Targets., 9(4), pp. 639-50. Huntington Study Group, 2006. Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial.. Neurology, 66(3), pp. 366-72. Jankovic, J. Ashizawa, T., 2008. Huntington's disease.. In: J. Noweworthy, ed. Neurological Therapeutics: Principles and Practice. London: Martin Dunitz, pp. 2550-2561. Johnson, C. D. Davidson, B. L., 2010. Huntington's disease: progress toward effective disease-modifying treatments and a cure. Human Molecular Genetics, 19(R1), p. R98R102. Jones, C. et al., 2016. The societal cost of Huntington's disease: are we underestimating the burden?. Eur J Neurol., 23(10), p. 15881590. Killoran, A. Biglan, K., 2014. Current therapeutic options for Huntington's disease: good clinical practice versus evidence-based approaches?. Mov Disord, 29(11), pp. 1404-13. NIH, 2015. HTT gene. [Online] Available at: https://ghr.nlm.nih.gov/gene/HTT [Accessed 19 September 2017]. Rawlins, M. et al., 2016. The Prevalence of Huntington's Disease.. Neuroepidemiology, 46(2), pp. 144-53. Raymond, L. A. et al., 2011. Pathophysiology of Huntingtons Disease: Time-Dependent Alterations in Synaptic and Receptor Function. Neuroscience, 15(198), pp. 252-273. Rosas, H. D. et al., 2008. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity.. Brain, 131(4), pp. 1057-1068. Vamos, M., Hambridge, J., Edwards, M. Conaghan, J., 2007. The Impact of Huntingtons Disease on Family Life. Psychosomatics, 48(5), pp. 400-405. Warby, S. C., Graham, R. K. Hayden, M. R., 2014. Huntington Disease. In: R. Pagon, M. Adam H. Ardinger, eds. Gene Reviews. Seattle: University pf Washington. Williams, J. et al., 2009. The emotional experiences of family carers in Huntington disease. J Adv Nurs, 65(4), pp. 789-98. Zuccato, C., Valenza, M. Cattaneo, E., 2010. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev., 905(81), pp. 905-981.